A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia

Izidore S. Lossos; Vered Bogomolski-Yahalome; Orly Yehuda; Susana Ben-Neriah; Dina Ben-Yehuda; Rachel Leizerowitz; Aaron Polliack

doi:10.1016/S0165-4608(98)00035-1

A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia

Izidore S. Lossos^*, Vered Bogomolski-Yahalome, Orly Yehuda, Susana Ben-Neriah, Dina Ben-Yehuda, Rachel Leizerowitz, Aaron Polliack

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

A novel and as yet unrecorded translocation, (1;2)(p34;p21-22), detected in a patient with acute myeloid leukemia (AML) is reported. The leukemia-in this case, AML-M4-showed a rapidly progressive fatal course despite an early transient response to aggressive chemotherapy. In this patient, the leukemic cells showed a novel balanced translocation, (1;2)(p34;p21-22), in most of the metaphases at the time of diagnosis and during subsequent relapse. Interferon-inducible double-stranded RNA-dependent protein kinase (ds RNA- PK) is located in the chromosome region, 2p21-22, that was involved in the translocation in this case. The possible role of ds RNA-PK in leukemogenesis is briefly mentioned.

Original language	English
Pages (from-to)	78-79
Number of pages	2
Journal	Cancer Genetics and Cytogenetics
Volume	106
Issue number	1
DOIs	https://doi.org/10.1016/S0165-4608(98)00035-1
State	Published - Oct 1998
Externally published	Yes

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title = "A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia",

abstract = "A novel and as yet unrecorded translocation, (1;2)(p34;p21-22), detected in a patient with acute myeloid leukemia (AML) is reported. The leukemia-in this case, AML-M4-showed a rapidly progressive fatal course despite an early transient response to aggressive chemotherapy. In this patient, the leukemic cells showed a novel balanced translocation, (1;2)(p34;p21-22), in most of the metaphases at the time of diagnosis and during subsequent relapse. Interferon-inducible double-stranded RNA-dependent protein kinase (ds RNA- PK) is located in the chromosome region, 2p21-22, that was involved in the translocation in this case. The possible role of ds RNA-PK in leukemogenesis is briefly mentioned.",

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AU - Lossos, Izidore S.

AU - Bogomolski-Yahalome, Vered

AU - Yehuda, Orly

AU - Ben-Neriah, Susana

AU - Ben-Yehuda, Dina

AU - Leizerowitz, Rachel

AU - Polliack, Aaron

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AB - A novel and as yet unrecorded translocation, (1;2)(p34;p21-22), detected in a patient with acute myeloid leukemia (AML) is reported. The leukemia-in this case, AML-M4-showed a rapidly progressive fatal course despite an early transient response to aggressive chemotherapy. In this patient, the leukemic cells showed a novel balanced translocation, (1;2)(p34;p21-22), in most of the metaphases at the time of diagnosis and during subsequent relapse. Interferon-inducible double-stranded RNA-dependent protein kinase (ds RNA- PK) is located in the chromosome region, 2p21-22, that was involved in the translocation in this case. The possible role of ds RNA-PK in leukemogenesis is briefly mentioned.

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A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia

Abstract

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