A Nuclear Magnetic Resonance Study of Sphingomyelin in Bilayer Systems

C. F. Schmidt, Y. Barenholz, T. E. Thompson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

118 Scopus citations

Abstract

The physical properties of small single-walled vesicles composed of the zwitterionic phospholipid sphingomyelin have been studied using 1H and 31P nuclear magnetic resonance spectroscopy. The temperature variation of proton line widths and spin-lattice relaxation times and the chemical shift behavior for sphingomyelin vesicles are compared with results previously determined for phosphatidylcholine vesicles. Differences between the two systems are interpreted as indications of the presence of both inter- and intramolecular hydrogen bonding in sphingomyelin bilayers.

Original languageEnglish
Pages (from-to)2649-2656
Number of pages8
JournalBiochemistry
Volume16
Issue number12
DOIs
StatePublished - 1 Jun 1977
Externally publishedYes

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