A nucleotide binding motif in hepatitis C virus (HCV) NS4b mediates HCV RNA replication

Shirit Einav; Menashe Elazar; Tsafi Danieli; Jeffrey S. Glenn

doi:10.1128/JVI.78.20.11288-11295.2004

A nucleotide binding motif in hepatitis C virus (HCV) NS4b mediates HCV RNA replication

Shirit Einav, Menashe Elazar, Tsafi Danieli, Jeffrey S. Glenn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Hepatitis C virus (HCV) is a major cause of viral hepatitis. There is no effective therapy for most patients. We have identified a nucleotide binding motif (NBM) in one of the virus's nonstructural proteins, NS4B. This structural motif binds and hydrolyzes GTP and is conserved across HCV isolates. Genetically disrupting the NBM impairs GTP binding and hydrolysis and dramatically inhibits HCV RNA replication. These results have exciting implications for the HCV life cycle and novel antiviral strategies.

Original language	English
Pages (from-to)	11288-11295
Number of pages	8
Journal	Journal of Virology
Volume	78
Issue number	20
DOIs	https://doi.org/10.1128/JVI.78.20.11288-11295.2004
State	Published - Oct 2004
Externally published	Yes

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10.1128/JVI.78.20.11288-11295.2004

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AB - Hepatitis C virus (HCV) is a major cause of viral hepatitis. There is no effective therapy for most patients. We have identified a nucleotide binding motif (NBM) in one of the virus's nonstructural proteins, NS4B. This structural motif binds and hydrolyzes GTP and is conserved across HCV isolates. Genetically disrupting the NBM impairs GTP binding and hydrolysis and dramatically inhibits HCV RNA replication. These results have exciting implications for the HCV life cycle and novel antiviral strategies.

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A nucleotide binding motif in hepatitis C virus (HCV) NS4b mediates HCV RNA replication

Abstract

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