A nucleotide binding motif in hepatitis C virus (HCV) NS4b mediates HCV RNA replication

Shirit Einav, Menashe Elazar, Tsafi Danieli, Jeffrey S. Glenn*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

Hepatitis C virus (HCV) is a major cause of viral hepatitis. There is no effective therapy for most patients. We have identified a nucleotide binding motif (NBM) in one of the virus's nonstructural proteins, NS4B. This structural motif binds and hydrolyzes GTP and is conserved across HCV isolates. Genetically disrupting the NBM impairs GTP binding and hydrolysis and dramatically inhibits HCV RNA replication. These results have exciting implications for the HCV life cycle and novel antiviral strategies.

Original languageAmerican English
Pages (from-to)11288-11295
Number of pages8
JournalJournal of Virology
Volume78
Issue number20
DOIs
StatePublished - Oct 2004
Externally publishedYes

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