A possible involvement of solvent-induced interactions in drug design

Hongwu Wang; Arieh Ben-Naim

doi:10.1021/jm950430d

A possible involvement of solvent-induced interactions in drug design

Hongwu Wang, Arieh Ben-Naim^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

We propose to study a new factor in designing new drugs. Most approaches to the drug design problem focus on the direct interactions between the drug and the corresponding target. We propose to study specific solvent-induced effects that can contribute to the binding Gibbs energy between the drug and its target. We estimate that these indirect effects will contribute significantly to the binding affinity and hopefully improve the clinical efficiency of the drugs.

Original language	English
Pages (from-to)	1531-1539
Number of pages	9
Journal	Journal of Medicinal Chemistry
Volume	39
Issue number	7
DOIs	https://doi.org/10.1021/jm950430d
State	Published - 29 Mar 1996

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10.1021/jm950430d

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A possible involvement of solvent-induced interactions in drug design

Abstract

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