A problem of persistence: Still more questions than answers?

Nathalie Q. Balaban, Kenn Gerdes, Kim Lewis, John D. McKinney

Research output: Contribution to journalReview articlepeer-review

208 Scopus citations

Abstract

The current antibiotic resistance crisis has led to increased pressure to prioritize strategies to tackle the issue, with a strong focus being placed on the development of novel antimicrobials. However, one major obstacle that is often overlooked is persister cells, which are refractory to antibiotic treatment. Tackling persistence is a challenge because these cell types are extremely difficult to study and, consequently, little is known about their physiology and the factors that lead to their emergence. Here, four experts contemplate the main physiological features that define persistence and the implications of persistence for antibiotic treatment regimens, and consider what the study of bacterial persistence has taught us about the heterogeneity of bacterial populations.

Original languageAmerican English
Pages (from-to)587-591
Number of pages5
JournalNature Reviews Microbiology
Volume11
Issue number8
DOIs
StatePublished - Aug 2013

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