TY - JOUR
T1 - A protective human monoclonal IgA antibody produced in vitro
T2 - Anti‐pneumococcal antibody engendered by Epstein‐Barr virus‐immortalized cell line
AU - Steinitz, Michael
AU - Tamir, Sara
AU - Ferne, Mina
AU - Goldfarb, Ada
PY - 1986
Y1 - 1986
N2 - Human lymphocytes that produce anti‐pneumococcal antibodies were separated and immortalized by Epstein‐Barr virus and then cloned. One clone (NAD‐Sel) produces an IgA, x antibody which is specific for the polysaccharides of type 8 pneumococcus, while not reactive with any of the polysaccharides derived from 24 other pneumococcal strains. The antibody, which is present in the cell supernatant as monomer and polymer, binds to protein A and does not fix complement. When incubated in vitro with type 8 pneumococci, it induces direct killing and increases the opsonization of these bacteria by mouse macrophages.
AB - Human lymphocytes that produce anti‐pneumococcal antibodies were separated and immortalized by Epstein‐Barr virus and then cloned. One clone (NAD‐Sel) produces an IgA, x antibody which is specific for the polysaccharides of type 8 pneumococcus, while not reactive with any of the polysaccharides derived from 24 other pneumococcal strains. The antibody, which is present in the cell supernatant as monomer and polymer, binds to protein A and does not fix complement. When incubated in vitro with type 8 pneumococci, it induces direct killing and increases the opsonization of these bacteria by mouse macrophages.
UR - http://www.scopus.com/inward/record.url?scp=0022653527&partnerID=8YFLogxK
U2 - 10.1002/eji.1830160214
DO - 10.1002/eji.1830160214
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C2 - 3007166
AN - SCOPUS:0022653527
SN - 0014-2980
VL - 16
SP - 187
EP - 193
JO - European Journal of Immunology
JF - European Journal of Immunology
IS - 2
ER -