Abstract
Human lymphocytes that produce anti‐pneumococcal antibodies were separated and immortalized by Epstein‐Barr virus and then cloned. One clone (NAD‐Sel) produces an IgA, x antibody which is specific for the polysaccharides of type 8 pneumococcus, while not reactive with any of the polysaccharides derived from 24 other pneumococcal strains. The antibody, which is present in the cell supernatant as monomer and polymer, binds to protein A and does not fix complement. When incubated in vitro with type 8 pneumococci, it induces direct killing and increases the opsonization of these bacteria by mouse macrophages.
| Original language | English |
|---|---|
| Pages (from-to) | 187-193 |
| Number of pages | 7 |
| Journal | European Journal of Immunology |
| Volume | 16 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1986 |
| Externally published | Yes |
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SDG 3 Good Health and Well-being
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