A putative physiological role of hypothalamic CNTF in the control of energy homeostasis

C. M. Vacher*, D. Crépin, A. Aubourg, O. Couvreur, V. Bailleux, V. Nicolas, J. Férézou, D. Gripois, A. Gertler, M. Taouis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Administration of CNTF durably reduces food intake and body weight in obese humans and rodent models. However, the involvement of endogenous CNTF in the central regulation of energy homeostasis needs to be elucidated. Here, we demonstrate that CNTF and its receptor are expressed in the arcuate nucleus, a key hypothalamic region controlling food intake, and that CNTF levels are inversely correlated to body weight in rats fed a high-sucrose diet. Thus endogenous CNTF may act, in some individuals, as a protective factor against weight gain during hypercaloric diet and could account for individual differences in the susceptibility to obesity.

Original languageEnglish
Pages (from-to)3832-3838
Number of pages7
JournalFEBS Letters
Volume582
Issue number27
DOIs
StatePublished - 12 Nov 2008

Keywords

  • Arcuate nucleus
  • CNTF
  • Food intake
  • Obesity
  • Unbalanced diet

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