A putative physiological role of hypothalamic CNTF in the control of energy homeostasis

C. M. Vacher; D. Crépin; A. Aubourg; O. Couvreur; V. Bailleux; V. Nicolas; J. Férézou; D. Gripois; A. Gertler; M. Taouis

doi:10.1016/j.febslet.2008.10.018

A putative physiological role of hypothalamic CNTF in the control of energy homeostasis

C. M. Vacher^*
, D. Crépin
, A. Aubourg
, O. Couvreur
, V. Bailleux
, V. Nicolas
, J. Férézou
, D. Gripois
, A. Gertler
, M. Taouis

^*Corresponding author for this work

Institute of Biochemistry, Food Science and Nutrition

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Administration of CNTF durably reduces food intake and body weight in obese humans and rodent models. However, the involvement of endogenous CNTF in the central regulation of energy homeostasis needs to be elucidated. Here, we demonstrate that CNTF and its receptor are expressed in the arcuate nucleus, a key hypothalamic region controlling food intake, and that CNTF levels are inversely correlated to body weight in rats fed a high-sucrose diet. Thus endogenous CNTF may act, in some individuals, as a protective factor against weight gain during hypercaloric diet and could account for individual differences in the susceptibility to obesity.

Original language	English
Pages (from-to)	3832-3838
Number of pages	7
Journal	FEBS Letters
Volume	582
Issue number	27
DOIs	https://doi.org/10.1016/j.febslet.2008.10.018
State	Published - 12 Nov 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Arcuate nucleus
CNTF
Food intake
Obesity
Unbalanced diet

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10.1016/j.febslet.2008.10.018

Cite this

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title = "A putative physiological role of hypothalamic CNTF in the control of energy homeostasis",

abstract = "Administration of CNTF durably reduces food intake and body weight in obese humans and rodent models. However, the involvement of endogenous CNTF in the central regulation of energy homeostasis needs to be elucidated. Here, we demonstrate that CNTF and its receptor are expressed in the arcuate nucleus, a key hypothalamic region controlling food intake, and that CNTF levels are inversely correlated to body weight in rats fed a high-sucrose diet. Thus endogenous CNTF may act, in some individuals, as a protective factor against weight gain during hypercaloric diet and could account for individual differences in the susceptibility to obesity.",

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T1 - A putative physiological role of hypothalamic CNTF in the control of energy homeostasis

AU - Vacher, C. M.

AU - Crépin, D.

AU - Aubourg, A.

AU - Couvreur, O.

AU - Bailleux, V.

AU - Nicolas, V.

AU - Férézou, J.

AU - Gripois, D.

AU - Gertler, A.

AU - Taouis, M.

PY - 2008/11/12

Y1 - 2008/11/12

N2 - Administration of CNTF durably reduces food intake and body weight in obese humans and rodent models. However, the involvement of endogenous CNTF in the central regulation of energy homeostasis needs to be elucidated. Here, we demonstrate that CNTF and its receptor are expressed in the arcuate nucleus, a key hypothalamic region controlling food intake, and that CNTF levels are inversely correlated to body weight in rats fed a high-sucrose diet. Thus endogenous CNTF may act, in some individuals, as a protective factor against weight gain during hypercaloric diet and could account for individual differences in the susceptibility to obesity.

AB - Administration of CNTF durably reduces food intake and body weight in obese humans and rodent models. However, the involvement of endogenous CNTF in the central regulation of energy homeostasis needs to be elucidated. Here, we demonstrate that CNTF and its receptor are expressed in the arcuate nucleus, a key hypothalamic region controlling food intake, and that CNTF levels are inversely correlated to body weight in rats fed a high-sucrose diet. Thus endogenous CNTF may act, in some individuals, as a protective factor against weight gain during hypercaloric diet and could account for individual differences in the susceptibility to obesity.

KW - Arcuate nucleus

KW - CNTF

KW - Food intake

KW - Obesity

KW - Unbalanced diet

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JO - FEBS Letters

JF - FEBS Letters

IS - 27

ER -

A putative physiological role of hypothalamic CNTF in the control of energy homeostasis

Abstract

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Keywords

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