TY - JOUR
T1 - A relAS suppressor mutant allele of Bacillus subtilis which maps to relA and responds only to carbon limitation
AU - Gropp, Michal
AU - Eizenman, Einat
AU - Glaser, Gad
AU - Samarrai, Walied
AU - Rudner, Rivka
PY - 1994
Y1 - 1994
N2 - The histidine analog 3-amino-1,2,4-triazole (AT) was used for the selection of spontaneous AT-resistant revertants of a relA mutant of Bacillus subtilis. One of these revertants, L3, showed a unique phenotype; it did not respond to amino acid starvation, like the relA mutant, but it did respond to glucose starvation by the accumulation of (p)ppGpp, unlike its parent. Genetic analysis revealed that this suppressor mutant (relAS) allele mapped to the relA locus at 239° on the B. subtilis chromosome.
AB - The histidine analog 3-amino-1,2,4-triazole (AT) was used for the selection of spontaneous AT-resistant revertants of a relA mutant of Bacillus subtilis. One of these revertants, L3, showed a unique phenotype; it did not respond to amino acid starvation, like the relA mutant, but it did respond to glucose starvation by the accumulation of (p)ppGpp, unlike its parent. Genetic analysis revealed that this suppressor mutant (relAS) allele mapped to the relA locus at 239° on the B. subtilis chromosome.
KW - (p)ppGpp
KW - amino-acid starvation
KW - amino-triazole
KW - Stringent response
KW - suppressor
KW - transduction and transformation crosses
UR - http://www.scopus.com/inward/record.url?scp=0028345832&partnerID=8YFLogxK
U2 - 10.1016/0378-1119(94)90736-6
DO - 10.1016/0378-1119(94)90736-6
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C2 - 8125346
AN - SCOPUS:0028345832
SN - 0378-1119
VL - 140
SP - 91
EP - 96
JO - Gene
JF - Gene
IS - 1
ER -