TY - JOUR
T1 - A retrospective study of positive pressure ventilation in 58 dogs
T2 - Indications, prognostic factors and outcome
AU - Bruchim, Y.
AU - Aroch, I.
AU - Sisso, A.
AU - Kushnir, Y.
AU - Epstein, A.
AU - Kelmer, E.
AU - Segev, G.
PY - 2014/6
Y1 - 2014/6
N2 - OBJECTIVES: To assess the usefulness of clinical and clinicopathological parameters as prognostic markers of survival in dogs undergoing positive pressure ventilation. METHODS: Retrospective study of case records of 58 client-owned dogs undergoing positive pressure ventilation. Dogs were divided into two groups; inadequate oxygenation due to pulmonary parenchymal disease (Group 1) and inadequate ventilation (Group 2). RESULTS: Median duration of positive pressure ventilation was 30 (range 10 to 136) hours. Survival rate was 32% (19 dogs). Survivors were significantly younger (P<0·005) and had significantly higher (P<0·002) median PaO2/FiO2 ratio at 4 to 12 hours postinitiation of positive pressure ventilation, and immediately before weaning (P<0·006) compared to non-survivors. A receiver operator characteristics analysis of PaO2/FiO2 immediately before weaning as predictor of survival had an area under the curve of 0·76 (95% confidence interval 0·54 to 0·97), with optimal cut-off point of 252 mmHg, corresponding to a sensitivity and specificity of 0·80 and 0·79, respectively. The survival rates of dogs with PaO2/FiO2 less than 200 mmHg at 4 to 12 hours postinitiation of positive pressure ventilation, or immediately before weaning were 15% (3/20 dogs) and 6% (1/16 dogs), respectively. CLINICAL SIGNIFICANCE: The PaO2/FiO2 ratio is an early prognostic indicator of successful weaning in dogs undergoing positive pressure ventilation.
AB - OBJECTIVES: To assess the usefulness of clinical and clinicopathological parameters as prognostic markers of survival in dogs undergoing positive pressure ventilation. METHODS: Retrospective study of case records of 58 client-owned dogs undergoing positive pressure ventilation. Dogs were divided into two groups; inadequate oxygenation due to pulmonary parenchymal disease (Group 1) and inadequate ventilation (Group 2). RESULTS: Median duration of positive pressure ventilation was 30 (range 10 to 136) hours. Survival rate was 32% (19 dogs). Survivors were significantly younger (P<0·005) and had significantly higher (P<0·002) median PaO2/FiO2 ratio at 4 to 12 hours postinitiation of positive pressure ventilation, and immediately before weaning (P<0·006) compared to non-survivors. A receiver operator characteristics analysis of PaO2/FiO2 immediately before weaning as predictor of survival had an area under the curve of 0·76 (95% confidence interval 0·54 to 0·97), with optimal cut-off point of 252 mmHg, corresponding to a sensitivity and specificity of 0·80 and 0·79, respectively. The survival rates of dogs with PaO2/FiO2 less than 200 mmHg at 4 to 12 hours postinitiation of positive pressure ventilation, or immediately before weaning were 15% (3/20 dogs) and 6% (1/16 dogs), respectively. CLINICAL SIGNIFICANCE: The PaO2/FiO2 ratio is an early prognostic indicator of successful weaning in dogs undergoing positive pressure ventilation.
UR - http://www.scopus.com/inward/record.url?scp=84901841612&partnerID=8YFLogxK
U2 - 10.1111/jsap.12211
DO - 10.1111/jsap.12211
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C2 - 24697570
AN - SCOPUS:84901841612
SN - 0022-4510
VL - 55
SP - 314
EP - 319
JO - Journal of Small Animal Practice
JF - Journal of Small Animal Practice
IS - 6
ER -