A roadmap to disentangle the molecular etiology of schizophrenia

Peter Falkai; Owen Mike; Germeys Inez; Harrison Paul; Bilkei Gorzo Andras; Frangou Sophia; Consortium MEOS Consortium; Frangou Sophia; Bilkei Gorzo Andras; Bitter István; Crespo Facorro Benedicto; Marc De Hert; Dierks Thomas; Annabella Di Giorgio; Gjedde Albert; Paul J. Harrison; Kasper Siegfried; Lawrie Stephen; Leboyer Marion; Maier Wolfgang; Maron Eduard; Philip McGuire; Meyer Lindenberg Andreas; Nöthen Markus; Owen Mike; Ruhrmann Stephan; Schürhoff Franck; Shifman Sagiv; Stefanis Nicholas; Neeltje van Haren; Vaudano Elisabett; Vita Antonio

doi:10.1016/j.eurpsy.2008.02.006

A roadmap to disentangle the molecular etiology of schizophrenia

Peter Falkai^*, Owen Mike, Germeys Inez, Harrison Paul, Bilkei Gorzo Andras, Frangou Sophia, Consortium MEOS Consortium, Frangou Sophia, Bilkei Gorzo Andras, Bitter István, Crespo Facorro Benedicto, Marc De Hert, Dierks Thomas, Annabella Di Giorgio, Gjedde Albert, Paul J. Harrison, Kasper Siegfried, Lawrie Stephen, Leboyer Marion, Maier WolfgangMaron Eduard, Philip McGuire, Meyer Lindenberg Andreas, Nöthen Markus, Owen Mike, Ruhrmann Stephan, Schürhoff Franck, Shifman Sagiv, Stefanis Nicholas, Neeltje van Haren, Vaudano Elisabett, Vita Antonio

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Schizophrenia is a severe mental disorder striking mainly young adults and leading to life-long disability in a substantial portion of the sufferers. On the other hand, substantial knowledge about its etiology and pathogenesis is still lacking. Therefore the European Science Foundation (ESF) sponsored a meeting of a panel of European experts on schizophrenia research to discuss the state of art and future perspectives of key topics in this area. The fields covered genetics, epidemiology, animal models, molecular neuropathology and imaging. This was a first step to establish a network of European groups dedicated to Schizophrenia research. The coming calls of the frame work program will be used to strengthen this network in order to achieve substantial progress in understanding and treating this devastating illness.

Original language	English
Pages (from-to)	224-232
Number of pages	9
Journal	European Psychiatry
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.eurpsy.2008.02.006
State	Published - 1 Jun 2008
Externally published	Yes

Bibliographical note

Funding Information:
Two calls of the 6FTP-EU initiated intense activity among those European groups with a major interest in schizophrenia research. Several grant proposals were submitted but only the one around DECODE was funded. Subsequently a workshop sponsored by the European Science Foundation (ESF) took place at the Institute of Psychiatry in London at 26th of October 2007. During the 1 day workshop the topics genetics, epidemiology, molecular neuropathology, animal models and imaging were discussed. For each topic, one leading expert gave a 15-min introduction trying to answer the following questions within their special area of interest:

Keywords

Animal models
Development of pharmacotropic agents from target proteins
Epidemiology
Gene-environment interaction
Genetic of psychiatric illnesses
Genetics
Genetics, function of susceptibility genes
Imaging
Imaging and bipolar disorders
Imaging and early recognition
Imaging, molecular neuropathology
Large-scale clinical studies on schizophrenia
Molecular neuropathology, function of susceptibility genes

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10.1016/j.eurpsy.2008.02.006

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Falkai, P., Mike, O., Inez, G., Paul, H., Andras, B. G., Sophia, F., MEOS Consortium, C., Sophia, F., Andras, B. G., István, B., Benedicto, C. F., De Hert, M., Thomas, D., Di Giorgio, A., Albert, G., Harrison, P. J., Siegfried, K., Stephen, L., Marion, L., ... Antonio, V. (2008). A roadmap to disentangle the molecular etiology of schizophrenia. European Psychiatry, 23(4), 224-232. https://doi.org/10.1016/j.eurpsy.2008.02.006

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abstract = "Schizophrenia is a severe mental disorder striking mainly young adults and leading to life-long disability in a substantial portion of the sufferers. On the other hand, substantial knowledge about its etiology and pathogenesis is still lacking. Therefore the European Science Foundation (ESF) sponsored a meeting of a panel of European experts on schizophrenia research to discuss the state of art and future perspectives of key topics in this area. The fields covered genetics, epidemiology, animal models, molecular neuropathology and imaging. This was a first step to establish a network of European groups dedicated to Schizophrenia research. The coming calls of the frame work program will be used to strengthen this network in order to achieve substantial progress in understanding and treating this devastating illness.",

keywords = "Animal models, Development of pharmacotropic agents from target proteins, Epidemiology, Gene-environment interaction, Genetic of psychiatric illnesses, Genetics, Genetics, function of susceptibility genes, Imaging, Imaging and bipolar disorders, Imaging and early recognition, Imaging, molecular neuropathology, Large-scale clinical studies on schizophrenia, Molecular neuropathology, function of susceptibility genes",

author = "Peter Falkai and Owen Mike and Germeys Inez and Harrison Paul and Andras, {Bilkei Gorzo} and Frangou Sophia and {MEOS Consortium}, Consortium and Frangou Sophia and Andras, {Bilkei Gorzo} and Bitter Istv{\'a}n and Benedicto, {Crespo Facorro} and {De Hert}, Marc and Dierks Thomas and {Di Giorgio}, Annabella and Gjedde Albert and Harrison, {Paul J.} and Kasper Siegfried and Lawrie Stephen and Leboyer Marion and Maier Wolfgang and Maron Eduard and Philip McGuire and Andreas, {Meyer Lindenberg} and N{\"o}then Markus and Owen Mike and Ruhrmann Stephan and Sch{\"u}rhoff Franck and Shifman Sagiv and Stefanis Nicholas and {van Haren}, Neeltje and Vaudano Elisabett and Vita Antonio",

note = "Funding Information: Two calls of the 6FTP-EU initiated intense activity among those European groups with a major interest in schizophrenia research. Several grant proposals were submitted but only the one around DECODE was funded. Subsequently a workshop sponsored by the European Science Foundation (ESF) took place at the Institute of Psychiatry in London at 26th of October 2007. During the 1 day workshop the topics genetics, epidemiology, molecular neuropathology, animal models and imaging were discussed. For each topic, one leading expert gave a 15-min introduction trying to answer the following questions within their special area of interest: ",

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Falkai, P, Mike, O, Inez, G, Paul, H, Andras, BG, Sophia, F, MEOS Consortium, C, Sophia, F, Andras, BG, István, B, Benedicto, CF, De Hert, M, Thomas, D, Di Giorgio, A, Albert, G, Harrison, PJ, Siegfried, K, Stephen, L, Marion, L, Wolfgang, M, Eduard, M, McGuire, P, Andreas, ML, Markus, N, Mike, O, Stephan, R, Franck, S, Sagiv, S, Nicholas, S, van Haren, N, Elisabett, V & Antonio, V 2008, 'A roadmap to disentangle the molecular etiology of schizophrenia', European Psychiatry, vol. 23, no. 4, pp. 224-232. https://doi.org/10.1016/j.eurpsy.2008.02.006

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AU - Falkai, Peter

AU - Mike, Owen

AU - Inez, Germeys

AU - Paul, Harrison

AU - Andras, Bilkei Gorzo

AU - Sophia, Frangou

AU - MEOS Consortium, Consortium

AU - Sophia, Frangou

AU - Andras, Bilkei Gorzo

AU - István, Bitter

AU - Benedicto, Crespo Facorro

AU - De Hert, Marc

AU - Thomas, Dierks

AU - Di Giorgio, Annabella

AU - Albert, Gjedde

AU - Harrison, Paul J.

AU - Siegfried, Kasper

AU - Stephen, Lawrie

AU - Marion, Leboyer

AU - Wolfgang, Maier

AU - Eduard, Maron

AU - McGuire, Philip

AU - Andreas, Meyer Lindenberg

AU - Markus, Nöthen

AU - Mike, Owen

AU - Stephan, Ruhrmann

AU - Franck, Schürhoff

AU - Sagiv, Shifman

AU - Nicholas, Stefanis

AU - van Haren, Neeltje

AU - Elisabett, Vaudano

AU - Antonio, Vita

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N2 - Schizophrenia is a severe mental disorder striking mainly young adults and leading to life-long disability in a substantial portion of the sufferers. On the other hand, substantial knowledge about its etiology and pathogenesis is still lacking. Therefore the European Science Foundation (ESF) sponsored a meeting of a panel of European experts on schizophrenia research to discuss the state of art and future perspectives of key topics in this area. The fields covered genetics, epidemiology, animal models, molecular neuropathology and imaging. This was a first step to establish a network of European groups dedicated to Schizophrenia research. The coming calls of the frame work program will be used to strengthen this network in order to achieve substantial progress in understanding and treating this devastating illness.

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KW - Animal models

KW - Development of pharmacotropic agents from target proteins

KW - Epidemiology

KW - Gene-environment interaction

KW - Genetic of psychiatric illnesses

KW - Genetics

KW - Genetics, function of susceptibility genes

KW - Imaging

KW - Imaging and bipolar disorders

KW - Imaging and early recognition

KW - Imaging, molecular neuropathology

KW - Large-scale clinical studies on schizophrenia

KW - Molecular neuropathology, function of susceptibility genes

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AN - SCOPUS:46849107340

SN - 0924-9338

VL - 23

SP - 224

EP - 232

JO - European Psychiatry

JF - European Psychiatry

IS - 4

ER -

A roadmap to disentangle the molecular etiology of schizophrenia

Abstract

Bibliographical note

Keywords

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