A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C

Fang Yuan; Steven H.L. Verhelst; Galia Blum; Lisa M. Coussens; Matthew Bogyo

doi:10.1021/ja060835v

A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C

Fang Yuan, Steven H.L. Verhelst, Galia Blum, Lisa M. Coussens, Matthew Bogyo

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.

Original language	English
Pages (from-to)	5616-5617
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	17
DOIs	https://doi.org/10.1021/ja060835v
State	Published - 3 May 2006

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abstract = "Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.",

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AU - Yuan, Fang

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AU - Coussens, Lisa M.

AU - Bogyo, Matthew

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AB - Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.

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A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C

Abstract

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