A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C

Fang Yuan; Steven H.L. Verhelst; Galia Blum; Lisa M. Coussens; Matthew Bogyo

doi:10.1021/ja060835v

A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C

Fang Yuan
, Steven H.L. Verhelst
, Galia Blum
, Lisa M. Coussens
, Matthew Bogyo

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.

Original language	English
Pages (from-to)	5616-5617
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	17
DOIs	https://doi.org/10.1021/ja060835v
State	Published - 3 May 2006

Access to Document

10.1021/ja060835v

Cite this

@article{4887b14b1d4e4351b1b328beee78bb3b,

title = "A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C",

abstract = "Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.",

author = "Fang Yuan and Verhelst, \{Steven H.L.\} and Galia Blum and Coussens, \{Lisa M.\} and Matthew Bogyo",

year = "2006",

month = may,

day = "3",

doi = "10.1021/ja060835v",

language = "אנגלית",

volume = "128",

pages = "5616--5617",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "17",

}

TY - JOUR

T1 - A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C

AU - Yuan, Fang

AU - Verhelst, Steven H.L.

AU - Blum, Galia

AU - Coussens, Lisa M.

AU - Bogyo, Matthew

PY - 2006/5/3

Y1 - 2006/5/3

N2 - Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.

AB - Dipeptidyl peptidase I is involved in the activation of a number of disease-related proteases by removal of N-terminal prodipeptides. We here report a selective activity-based probe for monitoring dipeptidyl peptidase I activity in whole proteomes as well as in intact cells, without labeling of closely related enzyme family members.

UR - https://www.scopus.com/pages/publications/33646594411

U2 - 10.1021/ja060835v

DO - 10.1021/ja060835v

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 16637611

AN - SCOPUS:33646594411

SN - 0002-7863

VL - 128

SP - 5616

EP - 5617

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 17

ER -

A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C

Abstract

Access to Document

Other files and links

Fingerprint

Cite this