A sensitive assay to evaluate antistreptococcal antibodies using an in vitro-produced monoclonal human rheumatoid factor.

A. Avital; S. Tamir; M. Faran; M. Steinitz

A sensitive assay to evaluate antistreptococcal antibodies using an in vitro-produced monoclonal human rheumatoid factor.

A. Avital^*
, S. Tamir
, M. Faran
, M. Steinitz

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

Abstract

A human monoclonal rheumatoid factor (RF) produced in vitro by an Epstein-Barr virus (EBV) immortalized cell line is used in an assay to detect and quantitate antibodies directed against streptococcal antigens in human sera. The assay, based on the binding of the rheumatoid factor to IgG-immune complexes, applies this monoclonal antibody in its iodinated form. The assay can easily quantitate IgG-antistreptococcal antibodies and enables the quantitation of these specific antibodies in sera that contain even very low titers.

Original language	English
Pages (from-to)	75-79
Number of pages	5
Journal	Diagnostic Immunology
Volume	1
Issue number	2
State	Published - 1983

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Cite this

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abstract = "A human monoclonal rheumatoid factor (RF) produced in vitro by an Epstein-Barr virus (EBV) immortalized cell line is used in an assay to detect and quantitate antibodies directed against streptococcal antigens in human sera. The assay, based on the binding of the rheumatoid factor to IgG-immune complexes, applies this monoclonal antibody in its iodinated form. The assay can easily quantitate IgG-antistreptococcal antibodies and enables the quantitation of these specific antibodies in sera that contain even very low titers.",

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AB - A human monoclonal rheumatoid factor (RF) produced in vitro by an Epstein-Barr virus (EBV) immortalized cell line is used in an assay to detect and quantitate antibodies directed against streptococcal antigens in human sera. The assay, based on the binding of the rheumatoid factor to IgG-immune complexes, applies this monoclonal antibody in its iodinated form. The assay can easily quantitate IgG-antistreptococcal antibodies and enables the quantitation of these specific antibodies in sera that contain even very low titers.

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A sensitive assay to evaluate antistreptococcal antibodies using an in vitro-produced monoclonal human rheumatoid factor.

Abstract

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