TY - JOUR
T1 - A Shape Memory Acrylamide/DNA Hydrogel Exhibiting Switchable Dual pH-Responsiveness
AU - Hu, Yuwei
AU - Lu, Chun Hua
AU - Guo, Weiwei
AU - Aleman-Garcia, Miguel Angel
AU - Ren, Jiangtao
AU - Willner, Itamar
N1 - Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2015/11/25
Y1 - 2015/11/25
N2 - Shape memory acrylamide/DNA hydrogels include two different crosslinkers as stabilizing elements. The triggered dissociation of one of the crosslinking elements transforms the shaped hydrogel into an arbitrarily shaped (or shapeless) quasi-liquid state. The remaining crosslinking element, present in the quasi-liquid, provides an internal memory that restores the original shaped hydrogel upon the stimulus-triggered regeneration of the second crosslinking element. Two pH-sensitive shape memory hydrogels, forming Hoogsten-type triplex DNA structures, are described. In one system, the shaped hydrogel is stabilized at pH = 7.0 by two different duplex crosslinkers, and the transition of the hydrogel into the shapeless quasi-liquid proceeds at pH = 5.0 by separating one of the crosslinking units into a protonated cytosine-guanine-cytosine (C-G·C+) triplex. The second shaped hydrogel is stabilized at pH = 7.0, by cooperative duplex and thymine-adenine-thymine triplex (T-A·T) bridges. At pH = 10.0, the triplex units separate, leading to the dissociation of the hydrogel into the quasi-liquid state. The cyclic, pH-stimulated transitions of the two systems between shaped hydrogels and shapeless states are demonstrated. Integrating the two hydrogels into a shaped "two-arrowhead" hybrid structure allows the pH-stimulated cyclic transitions of addressable domains of the hybrid between shaped and quasi-liquid states.
AB - Shape memory acrylamide/DNA hydrogels include two different crosslinkers as stabilizing elements. The triggered dissociation of one of the crosslinking elements transforms the shaped hydrogel into an arbitrarily shaped (or shapeless) quasi-liquid state. The remaining crosslinking element, present in the quasi-liquid, provides an internal memory that restores the original shaped hydrogel upon the stimulus-triggered regeneration of the second crosslinking element. Two pH-sensitive shape memory hydrogels, forming Hoogsten-type triplex DNA structures, are described. In one system, the shaped hydrogel is stabilized at pH = 7.0 by two different duplex crosslinkers, and the transition of the hydrogel into the shapeless quasi-liquid proceeds at pH = 5.0 by separating one of the crosslinking units into a protonated cytosine-guanine-cytosine (C-G·C+) triplex. The second shaped hydrogel is stabilized at pH = 7.0, by cooperative duplex and thymine-adenine-thymine triplex (T-A·T) bridges. At pH = 10.0, the triplex units separate, leading to the dissociation of the hydrogel into the quasi-liquid state. The cyclic, pH-stimulated transitions of the two systems between shaped hydrogels and shapeless states are demonstrated. Integrating the two hydrogels into a shaped "two-arrowhead" hybrid structure allows the pH-stimulated cyclic transitions of addressable domains of the hybrid between shaped and quasi-liquid states.
KW - DNA machines
KW - nucleic acids
KW - stimuli-responsive
KW - switches
KW - triplex
UR - http://www.scopus.com/inward/record.url?scp=84948431052&partnerID=8YFLogxK
U2 - 10.1002/adfm.201503134
DO - 10.1002/adfm.201503134
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AN - SCOPUS:84948431052
SN - 1616-301X
VL - 25
SP - 6867
EP - 6874
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 44
ER -