TY - JOUR
T1 - A Shape-Memory DNA-Based Hydrogel Exhibiting Two Internal Memories
AU - Hu, Yuwei
AU - Guo, Weiwei
AU - Kahn, Jason S.
AU - Aleman-Garcia, Miguel Angel
AU - Willner, Itamar
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2016/3/18
Y1 - 2016/3/18
N2 - The synthesis of a shape-memory acrylamide-DNA hydrogel that includes two internal memories is introduced. The hydrogel is stabilized, at pH 7.0, by two different pH-responsive oligonucleotide crosslinking units. At pH 10.0, one of the T-A-T triplex DNA bridging units is dissociated, resulting in the dissociation of the hydrogel into a shapeless quasi-liquid state that includes the other oligonucleotide bridges as internal memory. Similarly, at pH 5.0, the second type of bridges is separated, through the formation of C-G-C+ triplex units to yield the shapeless quasi-liquid state that includes the other oligonucleotide bridges as internal memory. By reversible pH triggering of the hydrogel between the values 10.0-7.0-5.0, the two internal memories cycle the material across shaped hydrogel and shapeless quasi-liquid states. The two memories enable the pH-dictated formation of two different hydrogel structures.
AB - The synthesis of a shape-memory acrylamide-DNA hydrogel that includes two internal memories is introduced. The hydrogel is stabilized, at pH 7.0, by two different pH-responsive oligonucleotide crosslinking units. At pH 10.0, one of the T-A-T triplex DNA bridging units is dissociated, resulting in the dissociation of the hydrogel into a shapeless quasi-liquid state that includes the other oligonucleotide bridges as internal memory. Similarly, at pH 5.0, the second type of bridges is separated, through the formation of C-G-C+ triplex units to yield the shapeless quasi-liquid state that includes the other oligonucleotide bridges as internal memory. By reversible pH triggering of the hydrogel between the values 10.0-7.0-5.0, the two internal memories cycle the material across shaped hydrogel and shapeless quasi-liquid states. The two memories enable the pH-dictated formation of two different hydrogel structures.
KW - DNA
KW - gels
KW - nanostructures
KW - polymers
KW - shape-memory materials
UR - http://www.scopus.com/inward/record.url?scp=84977871231&partnerID=8YFLogxK
U2 - 10.1002/anie.201511201
DO - 10.1002/anie.201511201
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C2 - 26915713
AN - SCOPUS:84977871231
SN - 1433-7851
VL - 55
SP - 4210
EP - 4214
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 13
ER -