A simple and stable silica gel support for the oligodeoxyribonucleotide synthesis

Joseph Deutsch, Sason Cohen, Moshe Weisz, Jehoshua Katzhendler

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A simple and efficient synthesis of a solid support with a long chain polyamide spacer has been developed. The spacer was made by successive addition of ethylene-diamine and succinic anhydride. The obtained solid support gives very homogeneous 20 mer oligodeoxyribonucleotides, detected by HPLC and electrophoresis.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalNucleosides and Nucleotides
Volume5
Issue number3
DOIs
StatePublished - 1 Jul 1986

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