A simple and stable silica gel support for the oligodeoxyribonucleotide synthesis

Joseph Deutsch; Sason Cohen; Moshe Weisz; Jehoshua Katzhendler

doi:10.1080/07328318608069981

A simple and stable silica gel support for the oligodeoxyribonucleotide synthesis

Joseph Deutsch
, Sason Cohen
, Moshe Weisz
, Jehoshua Katzhendler

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A simple and efficient synthesis of a solid support with a long chain polyamide spacer has been developed. The spacer was made by successive addition of ethylene-diamine and succinic anhydride. The obtained solid support gives very homogeneous 20 mer oligodeoxyribonucleotides, detected by HPLC and electrophoresis.

Original language	English
Pages (from-to)	325-330
Number of pages	6
Journal	Nucleosides and Nucleotides
Volume	5
Issue number	3
DOIs	https://doi.org/10.1080/07328318608069981
State	Published - 1 Jul 1986

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10.1080/07328318608069981

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title = "A simple and stable silica gel support for the oligodeoxyribonucleotide synthesis",

abstract = "A simple and efficient synthesis of a solid support with a long chain polyamide spacer has been developed. The spacer was made by successive addition of ethylene-diamine and succinic anhydride. The obtained solid support gives very homogeneous 20 mer oligodeoxyribonucleotides, detected by HPLC and electrophoresis.",

author = "Joseph Deutsch and Sason Cohen and Moshe Weisz and Jehoshua Katzhendler",

year = "1986",

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doi = "10.1080/07328318608069981",

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AU - Deutsch, Joseph

AU - Cohen, Sason

AU - Weisz, Moshe

AU - Katzhendler, Jehoshua

PY - 1986/7/1

Y1 - 1986/7/1

N2 - A simple and efficient synthesis of a solid support with a long chain polyamide spacer has been developed. The spacer was made by successive addition of ethylene-diamine and succinic anhydride. The obtained solid support gives very homogeneous 20 mer oligodeoxyribonucleotides, detected by HPLC and electrophoresis.

AB - A simple and efficient synthesis of a solid support with a long chain polyamide spacer has been developed. The spacer was made by successive addition of ethylene-diamine and succinic anhydride. The obtained solid support gives very homogeneous 20 mer oligodeoxyribonucleotides, detected by HPLC and electrophoresis.

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A simple and stable silica gel support for the oligodeoxyribonucleotide synthesis

Abstract

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