A stem cell approach to cure type 1 diabetes

Aharon Helman, Douglas A. Melton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Treatment of type 1 diabetes with insulin injection is expensive, complicated, and insuffi-cient. While cadaveric islet transplantations coupled with immunosuppressants can cure diabetes, the scarcity of acceptable islets is problematic. Developmental research on pancreas formation has informed in vitro differentiation of human pluripotent stem cells into functional islets. Although generating β cells from stem cells offers a potential cure for type 1 diabetes, several challenges remain, including protecting the cells from the immune system.

Original languageAmerican English
Article numbera035741
Pages (from-to)1-10
Number of pages10
JournalCold Spring Harbor perspectives in biology
Issue number1
StatePublished - 2021
Externally publishedYes

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© 2021 Cold Spring Harbor Laboratory Press; all rights reserved;.


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