TY - JOUR
T1 - A study on the in vitro degradation of poly(lactic acid)
AU - Migliaresi, C.
AU - Fambri1, L.
AU - Cohn, D.
PY - 1994
Y1 - 1994
N2 - The in vitro degradation of samples of L- and D, L-lactic acid polymers, P(L)LA and P(DL) LA respectively, having different molecular weights, morphology and/or geometry, has been studied through the determination of viscometric molecular weight, mass and mechanical properties as function of the immersion time in Ringer solution at 37°C. In particular have been compared the degradation kinetics of P(L) LA, amorphous and crystalline, and of P(L)LA and P(DL)LA having different molecular weight and sample geometry. From the molecular weight versus the degradation time data, a degradation rate has been defined, as the derivative of the function best fitting the data, normalized to the molecular weight of the polymer at each time. The behavior of the degradation rate curves, plotted against the degradation time, has been interpretated and compared with relation to the initial physical and geometrical characteristics of the PLA samples.
AB - The in vitro degradation of samples of L- and D, L-lactic acid polymers, P(L)LA and P(DL) LA respectively, having different molecular weights, morphology and/or geometry, has been studied through the determination of viscometric molecular weight, mass and mechanical properties as function of the immersion time in Ringer solution at 37°C. In particular have been compared the degradation kinetics of P(L) LA, amorphous and crystalline, and of P(L)LA and P(DL)LA having different molecular weight and sample geometry. From the molecular weight versus the degradation time data, a degradation rate has been defined, as the derivative of the function best fitting the data, normalized to the molecular weight of the polymer at each time. The behavior of the degradation rate curves, plotted against the degradation time, has been interpretated and compared with relation to the initial physical and geometrical characteristics of the PLA samples.
KW - crystallinity
KW - degradation
KW - morphology
KW - Poly(lactic acid)
UR - http://www.scopus.com/inward/record.url?scp=0028309277&partnerID=8YFLogxK
U2 - 10.1163/156856294X00220
DO - 10.1163/156856294X00220
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C2 - 8086385
AN - SCOPUS:0028309277
SN - 0920-5063
VL - 5
SP - 591
EP - 606
JO - Journal of Biomaterials Science, Polymer Edition
JF - Journal of Biomaterials Science, Polymer Edition
IS - 6
ER -