A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Baptiste Janela; Amit A. Patel; Mai Chan Lau; Chi Ching Goh; Rasha Msallam; Wan Ting Kong; Michael Fehlings; Sandra Hubert; Josephine Lum; Yannick Simoni; Benoit Malleret; Francesca Zolezzi; Jinmiao Chen; Michael Poidinger; Ansuman T. Satpathy; Carlos Briseno; Christian Wohn; Bernard Malissen; Kenneth M. Murphy; Alexander A. Maini; Leen Vanhoutte; Martin Guilliams; Emmanuel Vial; Laurent Hennequin; Evan Newell; Lai Guan Ng; Philippe Musette; Simon Yona; Feriel Hacini-Rachinel; Florent Ginhoux

doi:10.1016/j.immuni.2019.03.001

A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Baptiste Janela, Amit A. Patel, Mai Chan Lau, Chi Ching Goh, Rasha Msallam, Wan Ting Kong, Michael Fehlings, Sandra Hubert, Josephine Lum, Yannick Simoni, Benoit Malleret, Francesca Zolezzi, Jinmiao Chen, Michael Poidinger, Ansuman T. Satpathy, Carlos Briseno, Christian Wohn, Bernard Malissen, Kenneth M. Murphy, Alexander A. MainiLeen Vanhoutte, Martin Guilliams, Emmanuel Vial, Laurent Hennequin, Evan Newell, Lai Guan Ng, Philippe Musette, Simon Yona, Feriel Hacini-Rachinel, Florent Ginhoux^*

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.

Original language	English
Pages (from-to)	1069-1083.e8
Journal	Immunity
Volume	50
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2019.03.001
State	Published - 16 Apr 2019

Bibliographical note

Funding Information:
This work was supported by the Singapore Immunology Network (SIgN) core grant and in part by a grant from Nestlé Skin Health R&D/GALDERMA. We thank L. Robinson for critical review and editing of the manuscript. Generation and validation of the Xcr1-IRES-iCre-GSG-2A-TEAL gene-targeted mice were supported by the DCBiol Labex (ANR-11-LABEX-0043 and ANR-10-IDEX-0001-02 PSL) and PHENOMIN. We thank the SIgN Immunomonitoring platform, supported by Biomedical Research Council Industry Alignment Fund (BMRC IAF) grant 311006 and BMRC transition funds #H16/99/b0/011. B.J. A.A.P. M.C.L. C.C.G. R.M. W.T.K. M.F. S.H. J.L. Y.S. B.M. F.Z. J.C. M.P. A.T.S. C.B. C.W. B.M. K.M.M. A.A.M. L.V. M.G. E.V. L.H. E.N. L.G.N. P.M. S.Y. F.H.-R. and F.G. participated in the planning, design, and interpretation of experiments and results. B.J. A.A.P. M.C.L. C.C.G. R.M. W.T.K. M.F. S.H. J.L. and A.T.S. carried out experiments and/or analyzed data. B.J. and F.G. wrote the manuscript. B.J. F.G. E.V. and F.H.-R. have one patent related to this work: International Publication Number WO 2018/224614 Al.

Funding Information:
This work was supported by the Singapore Immunology Network (SIgN) core grant and in part by a grant from Nestlé Skin Health R&D/GALDERMA . We thank L. Robinson for critical review and editing of the manuscript. Generation and validation of the Xcr1-IRES-iCre-GSG-2A-TEAL gene-targeted mice were supported by the DCBiol Labex ( ANR-11-LABEX-0043 and ANR-10-IDEX-0001-02 PSL ) and PHENOMIN . We thank the SIgN Immunomonitoring platform , supported by Biomedical Research Council Industry Alignment Fund (BMRC IAF) grant 311006 and BMRC transition funds #H16/99/b0/011 .

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

VEGF
VEGFR
XCR1
activation
cDC1
dendritic cell
langerin
monocyte
neutrophil
recruitment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Janela, B., Patel, A. A., Lau, M. C., Goh, C. C., Msallam, R., Kong, W. T., Fehlings, M., Hubert, S., Lum, J., Simoni, Y., Malleret, B., Zolezzi, F., Chen, J., Poidinger, M., Satpathy, A. T., Briseno, C., Wohn, C., Malissen, B., Murphy, K. M., ... Ginhoux, F. (2019). A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils. Immunity, 50(4), 1069-1083.e8. https://doi.org/10.1016/j.immuni.2019.03.001

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title = "A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils",

abstract = "Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.",

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author = "Baptiste Janela and Patel, {Amit A.} and Lau, {Mai Chan} and Goh, {Chi Ching} and Rasha Msallam and Kong, {Wan Ting} and Michael Fehlings and Sandra Hubert and Josephine Lum and Yannick Simoni and Benoit Malleret and Francesca Zolezzi and Jinmiao Chen and Michael Poidinger and Satpathy, {Ansuman T.} and Carlos Briseno and Christian Wohn and Bernard Malissen and Murphy, {Kenneth M.} and Maini, {Alexander A.} and Leen Vanhoutte and Martin Guilliams and Emmanuel Vial and Laurent Hennequin and Evan Newell and Ng, {Lai Guan} and Philippe Musette and Simon Yona and Feriel Hacini-Rachinel and Florent Ginhoux",

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Janela, B, Patel, AA, Lau, MC, Goh, CC, Msallam, R, Kong, WT, Fehlings, M, Hubert, S, Lum, J, Simoni, Y, Malleret, B, Zolezzi, F, Chen, J, Poidinger, M, Satpathy, AT, Briseno, C, Wohn, C, Malissen, B, Murphy, KM, Maini, AA, Vanhoutte, L, Guilliams, M, Vial, E, Hennequin, L, Newell, E, Ng, LG, Musette, P, Yona, S, Hacini-Rachinel, F & Ginhoux, F 2019, 'A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils', Immunity, vol. 50, no. 4, pp. 1069-1083.e8. https://doi.org/10.1016/j.immuni.2019.03.001

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AU - Janela, Baptiste

AU - Patel, Amit A.

AU - Lau, Mai Chan

AU - Goh, Chi Ching

AU - Msallam, Rasha

AU - Kong, Wan Ting

AU - Fehlings, Michael

AU - Hubert, Sandra

AU - Lum, Josephine

AU - Simoni, Yannick

AU - Malleret, Benoit

AU - Zolezzi, Francesca

AU - Chen, Jinmiao

AU - Poidinger, Michael

AU - Satpathy, Ansuman T.

AU - Briseno, Carlos

AU - Wohn, Christian

AU - Malissen, Bernard

AU - Murphy, Kenneth M.

AU - Maini, Alexander A.

AU - Vanhoutte, Leen

AU - Guilliams, Martin

AU - Vial, Emmanuel

AU - Hennequin, Laurent

AU - Newell, Evan

AU - Ng, Lai Guan

AU - Musette, Philippe

AU - Yona, Simon

AU - Hacini-Rachinel, Feriel

AU - Ginhoux, Florent

PY - 2019/4/16

Y1 - 2019/4/16

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AB - Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.

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KW - VEGFR

KW - XCR1

KW - activation

KW - cDC1

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ER -

A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Abstract

Bibliographical note

Keywords

UN SDGs

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