A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Baptiste Janela, Amit A. Patel, Mai Chan Lau, Chi Ching Goh, Rasha Msallam, Wan Ting Kong, Michael Fehlings, Sandra Hubert, Josephine Lum, Yannick Simoni, Benoit Malleret, Francesca Zolezzi, Jinmiao Chen, Michael Poidinger, Ansuman T. Satpathy, Carlos Briseno, Christian Wohn, Bernard Malissen, Kenneth M. Murphy, Alexander A. MainiLeen Vanhoutte, Martin Guilliams, Emmanuel Vial, Laurent Hennequin, Evan Newell, Lai Guan Ng, Philippe Musette, Simon Yona, Feriel Hacini-Rachinel, Florent Ginhoux*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.

Original languageAmerican English
Pages (from-to)1069-1083.e8
JournalImmunity
Volume50
Issue number4
DOIs
StatePublished - 16 Apr 2019

Bibliographical note

Funding Information:
This work was supported by the Singapore Immunology Network (SIgN) core grant and in part by a grant from Nestlé Skin Health R&D/GALDERMA. We thank L. Robinson for critical review and editing of the manuscript. Generation and validation of the Xcr1-IRES-iCre-GSG-2A-TEAL gene-targeted mice were supported by the DCBiol Labex (ANR-11-LABEX-0043 and ANR-10-IDEX-0001-02 PSL) and PHENOMIN. We thank the SIgN Immunomonitoring platform, supported by Biomedical Research Council Industry Alignment Fund (BMRC IAF) grant 311006 and BMRC transition funds #H16/99/b0/011. B.J. A.A.P. M.C.L. C.C.G. R.M. W.T.K. M.F. S.H. J.L. Y.S. B.M. F.Z. J.C. M.P. A.T.S. C.B. C.W. B.M. K.M.M. A.A.M. L.V. M.G. E.V. L.H. E.N. L.G.N. P.M. S.Y. F.H.-R. and F.G. participated in the planning, design, and interpretation of experiments and results. B.J. A.A.P. M.C.L. C.C.G. R.M. W.T.K. M.F. S.H. J.L. and A.T.S. carried out experiments and/or analyzed data. B.J. and F.G. wrote the manuscript. B.J. F.G. E.V. and F.H.-R. have one patent related to this work: International Publication Number WO 2018/224614 Al.

Funding Information:
This work was supported by the Singapore Immunology Network (SIgN) core grant and in part by a grant from Nestlé Skin Health R&D/GALDERMA . We thank L. Robinson for critical review and editing of the manuscript. Generation and validation of the Xcr1-IRES-iCre-GSG-2A-TEAL gene-targeted mice were supported by the DCBiol Labex ( ANR-11-LABEX-0043 and ANR-10-IDEX-0001-02 PSL ) and PHENOMIN . We thank the SIgN Immunomonitoring platform , supported by Biomedical Research Council Industry Alignment Fund (BMRC IAF) grant 311006 and BMRC transition funds #H16/99/b0/011 .

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

  • VEGF
  • VEGFR
  • XCR1
  • activation
  • cDC1
  • dendritic cell
  • langerin
  • monocyte
  • neutrophil
  • recruitment

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