A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Baptiste Janela; Amit A. Patel; Mai Chan Lau; Chi Ching Goh; Rasha Msallam; Wan Ting Kong; Michael Fehlings; Sandra Hubert; Josephine Lum; Yannick Simoni; Benoit Malleret; Francesca Zolezzi; Jinmiao Chen; Michael Poidinger; Ansuman T. Satpathy; Carlos Briseno; Christian Wohn; Bernard Malissen; Kenneth M. Murphy; Alexander A. Maini; Leen Vanhoutte; Martin Guilliams; Emmanuel Vial; Laurent Hennequin; Evan Newell; Lai Guan Ng; Philippe Musette; Simon Yona; Feriel Hacini-Rachinel; Florent Ginhoux

doi:10.1016/j.immuni.2019.03.001

A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Baptiste Janela
, Amit A. Patel
, Mai Chan Lau
, Chi Ching Goh
, Rasha Msallam
, Wan Ting Kong
, Michael Fehlings
, Sandra Hubert
, Josephine Lum
, Yannick Simoni
, Benoit Malleret
, Francesca Zolezzi
, Jinmiao Chen
, Michael Poidinger
, Ansuman T. Satpathy
, Carlos Briseno
, Christian Wohn
, Bernard Malissen
, Kenneth M. Murphy
, Alexander A. Maini

Leen Vanhoutte, Martin Guilliams, Emmanuel Vial, Laurent Hennequin, Evan Newell, Lai Guan Ng, Philippe Musette, Simon Yona, Feriel Hacini-Rachinel, Florent Ginhoux^*

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.

Original language	English
Pages (from-to)	1069-1083.e8
Journal	Immunity
Volume	50
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2019.03.001
State	Published - 16 Apr 2019

Bibliographical note

Funding Information:
This work was supported by the Singapore Immunology Network (SIgN) core grant and in part by a grant from Nestlé Skin Health R&D/GALDERMA. We thank L. Robinson for critical review and editing of the manuscript. Generation and validation of the Xcr1-IRES-iCre-GSG-2A-TEAL gene-targeted mice were supported by the DCBiol Labex (ANR-11-LABEX-0043 and ANR-10-IDEX-0001-02 PSL) and PHENOMIN. We thank the SIgN Immunomonitoring platform, supported by Biomedical Research Council Industry Alignment Fund (BMRC IAF) grant 311006 and BMRC transition funds #H16/99/b0/011. B.J. A.A.P. M.C.L. C.C.G. R.M. W.T.K. M.F. S.H. J.L. Y.S. B.M. F.Z. J.C. M.P. A.T.S. C.B. C.W. B.M. K.M.M. A.A.M. L.V. M.G. E.V. L.H. E.N. L.G.N. P.M. S.Y. F.H.-R. and F.G. participated in the planning, design, and interpretation of experiments and results. B.J. A.A.P. M.C.L. C.C.G. R.M. W.T.K. M.F. S.H. J.L. and A.T.S. carried out experiments and/or analyzed data. B.J. and F.G. wrote the manuscript. B.J. F.G. E.V. and F.H.-R. have one patent related to this work: International Publication Number WO 2018/224614 Al.

Funding Information:
This work was supported by the Singapore Immunology Network (SIgN) core grant and in part by a grant from Nestlé Skin Health R&D/GALDERMA . We thank L. Robinson for critical review and editing of the manuscript. Generation and validation of the Xcr1-IRES-iCre-GSG-2A-TEAL gene-targeted mice were supported by the DCBiol Labex ( ANR-11-LABEX-0043 and ANR-10-IDEX-0001-02 PSL ) and PHENOMIN . We thank the SIgN Immunomonitoring platform , supported by Biomedical Research Council Industry Alignment Fund (BMRC IAF) grant 311006 and BMRC transition funds #H16/99/b0/011 .

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

VEGF
VEGFR
XCR1
activation
cDC1
dendritic cell
langerin
monocyte
neutrophil
recruitment

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10.1016/j.immuni.2019.03.001

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Janela, B., Patel, A. A., Lau, M. C., Goh, C. C., Msallam, R., Kong, W. T., Fehlings, M., Hubert, S., Lum, J., Simoni, Y., Malleret, B., Zolezzi, F., Chen, J., Poidinger, M., Satpathy, A. T., Briseno, C., Wohn, C., Malissen, B., Murphy, K. M., ... Ginhoux, F. (2019). A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils. Immunity, 50(4), 1069-1083.e8. https://doi.org/10.1016/j.immuni.2019.03.001

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abstract = "Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.",

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Janela, B, Patel, AA, Lau, MC, Goh, CC, Msallam, R, Kong, WT, Fehlings, M, Hubert, S, Lum, J, Simoni, Y, Malleret, B, Zolezzi, F, Chen, J, Poidinger, M, Satpathy, AT, Briseno, C, Wohn, C, Malissen, B, Murphy, KM, Maini, AA, Vanhoutte, L, Guilliams, M, Vial, E, Hennequin, L, Newell, E, Ng, LG, Musette, P, Yona, S, Hacini-Rachinel, F & Ginhoux, F 2019, 'A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils', Immunity, vol. 50, no. 4, pp. 1069-1083.e8. https://doi.org/10.1016/j.immuni.2019.03.001

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AU - Patel, Amit A.

AU - Lau, Mai Chan

AU - Goh, Chi Ching

AU - Msallam, Rasha

AU - Kong, Wan Ting

AU - Fehlings, Michael

AU - Hubert, Sandra

AU - Lum, Josephine

AU - Simoni, Yannick

AU - Malleret, Benoit

AU - Zolezzi, Francesca

AU - Chen, Jinmiao

AU - Poidinger, Michael

AU - Satpathy, Ansuman T.

AU - Briseno, Carlos

AU - Wohn, Christian

AU - Malissen, Bernard

AU - Murphy, Kenneth M.

AU - Maini, Alexander A.

AU - Vanhoutte, Leen

AU - Guilliams, Martin

AU - Vial, Emmanuel

AU - Hennequin, Laurent

AU - Newell, Evan

AU - Ng, Lai Guan

AU - Musette, Philippe

AU - Yona, Simon

AU - Hacini-Rachinel, Feriel

AU - Ginhoux, Florent

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AB - Janela et al. find that during cutaneous bacterial infection, a minor subset of type I conventional dendritic cells (cDC1s) control neutrophil recruitment to the inflamed site and survival and function therein through the secretion of the cytokine VEGF-α. Skin cDC1s emerge as essential regulators of the innate response in cutaneous immunity and have roles beyond classical antigen presentation.

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KW - VEGFR

KW - XCR1

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KW - cDC1

KW - dendritic cell

KW - langerin

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JF - Immunity

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ER -

A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils

Abstract

Bibliographical note

Keywords

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