A survey of small RNA-encoding genes in Escherichia coli

Ruth Hershberg, Shoshy Altuvia, Hanah Margalit*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

220 Scopus citations


Small RNA (sRNA) molecules have gained much interest lately, as recent genome-wide studies have shown that they are widespread in a variety of organisms. The relatively small family of 10 known sRNA-encoding genes in Escherichia coli has been significantly expanded during the past two years with the discovery of 45 novel genes. Most of these genes are still uncharacterized and their cellular roles are unknown. In this survey we examined the sequence and genomic features of the 55 currently known sRNA-encoding genes in E.coli, attempting to identify their common characteristics. Such characterization is important for both expanding our understanding of this unique gene family and for improving the methods to predict and identify sRNA-encoding genes based on genomic information.

Original languageAmerican English
Pages (from-to)1813-1820
Number of pages8
JournalNucleic Acids Research
Issue number7
StatePublished - 1 Apr 2003

Bibliographical note

Funding Information:
We thank Elena Rivas for sending us unpublished data. This study was supported by a grant from the Human Frontier Science Program granted to H.M. and S.A.


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