A survey of small RNA-encoding genes in Escherichia coli

Ruth Hershberg; Shoshy Altuvia; Hanah Margalit

doi:10.1093/nar/gkg297

A survey of small RNA-encoding genes in Escherichia coli

Ruth Hershberg, Shoshy Altuvia, Hanah Margalit^*

^*Corresponding author for this work

Department of Microbiology and Molecular Genetics

Research output: Contribution to journal › Review article › peer-review

221 Scopus citations

Abstract

Small RNA (sRNA) molecules have gained much interest lately, as recent genome-wide studies have shown that they are widespread in a variety of organisms. The relatively small family of 10 known sRNA-encoding genes in Escherichia coli has been significantly expanded during the past two years with the discovery of 45 novel genes. Most of these genes are still uncharacterized and their cellular roles are unknown. In this survey we examined the sequence and genomic features of the 55 currently known sRNA-encoding genes in E.coli, attempting to identify their common characteristics. Such characterization is important for both expanding our understanding of this unique gene family and for improving the methods to predict and identify sRNA-encoding genes based on genomic information.

Original language	English
Pages (from-to)	1813-1820
Number of pages	8
Journal	Nucleic Acids Research
Volume	31
Issue number	7
DOIs	https://doi.org/10.1093/nar/gkg297
State	Published - 1 Apr 2003

Bibliographical note

Funding Information:
We thank Elena Rivas for sending us unpublished data. This study was supported by a grant from the Human Frontier Science Program granted to H.M. and S.A.

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10.1093/nar/gkg297

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A survey of small RNA-encoding genes in Escherichia coli

Abstract

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