TY - JOUR
T1 - A tale of two endothelins
T2 - the rise and fall of the corpus luteum
AU - Szymanska, Magdalena
AU - Basavaraja, Raghavendra
AU - Meidan, Rina
PY - 2024/12/1
Y1 - 2024/12/1
N2 - Endothelins are small 21 amino acid peptides that interact with G-protein-coupled receptors. They are highly conserved across species and play important roles in vascular biology as well as in disease development and progression. Endothelins, mainly endothelin-1 and endothelin-2, are intricately involved in ovarian function and metabolism. These two peptides differ only in two amino acids but are encoded by different genes, which suggests an independent regulation and a cell-specific mode of expression. This review aims to comprehensively discuss the distinct regulation and roles of endothelin-1 and endothelin-2 regarding corpus luteum function throughout its life span.
AB - Endothelins are small 21 amino acid peptides that interact with G-protein-coupled receptors. They are highly conserved across species and play important roles in vascular biology as well as in disease development and progression. Endothelins, mainly endothelin-1 and endothelin-2, are intricately involved in ovarian function and metabolism. These two peptides differ only in two amino acids but are encoded by different genes, which suggests an independent regulation and a cell-specific mode of expression. This review aims to comprehensively discuss the distinct regulation and roles of endothelin-1 and endothelin-2 regarding corpus luteum function throughout its life span.
UR - http://www.scopus.com/inward/record.url?scp=85212885128&partnerID=8YFLogxK
U2 - 10.1071/rd24158
DO - 10.1071/rd24158
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C2 - 39680472
AN - SCOPUS:85212885128
SN - 1031-3613
VL - 37
JO - Reproduction, Fertility and Development
JF - Reproduction, Fertility and Development
ER -