A tale of two species: Neural integration in zebrafish and monkeys

M. Joshua*, S. G. Lisberger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Selection of a model organism creates tension between competing constraints. The recent explosion of modern molecular techniques has revolutionized the analysis of neural systems in organisms that are amenable to genetic techniques. Yet, the non-human primate remains the gold-standard for the analysis of the neural basis of behavior, and as a bridge to the operation of the human brain. The challenge is to generalize across species in a way that exposes the operation of circuits as well as the relationship of circuits to behavior. Eye movements provide an opportunity to cross the bridge from mechanism to behavior through research on diverse species. Here, we review experiments and computational studies on a circuit function called "neural integration" that occurs in the brainstems of larval zebrafish, primates, and species "in between". We show that analysis of circuit structure using modern molecular and imaging approaches in zebrafish has remarkable explanatory power for details of the responses of integrator neurons in the monkey. The combination of research from the two species has led to a much stronger hypothesis for the implementation of the neural integrator than could have been achieved using either species alone.

Original languageAmerican English
Pages (from-to)80-91
Number of pages12
StatePublished - 8 Jun 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 IBRO.


  • Animal models
  • Brainstem
  • Eye movements
  • Monkey
  • Neural integrator
  • Zebrafish


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