A temperature sensitive mutant of a Chinese hamster cell line exhibiting high chromosomal breakage

A. Fainsod, R. Voss, P. Spann, R. Goitein, M. Marcus*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A temperature sensitive mutant exhibiting a very high level of chromosomal aberrations has been isolated from the Chinese hamster cell line E36. The chromosome aberrations, which include chromosome and chromatid breaks, multiradial configurations, dicentrics, and pulverizations, start to appear 1 h after a shift in temperature from 34°C to 40.5°C. The rate of sister chromatid exchange is not increased in this mutant. Analysis of somatic cell hybrids indicates that the mutation in this temperature sensitive mutant is dominant.

Original languageAmerican English
Pages (from-to)104-109
Number of pages6
JournalCytogenetics and Cell Genetics
Volume35
Issue number2
DOIs
StatePublished - 1983

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