A theoretical experimental method to determine the locus of desensitization

E. Buchman, H. Parnas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Consider a ligand-gated channel with n agonist binding sites which can undergo desensitization. We present a theoretical experimental procedure for pinpointing the principal receptor state from which there is a transition to the desensitized state. The method is based on the observation that the dependence of the slope of the time constant of desensitization vs agonist concentration, at low concentrations, represents the state from which desensitization occurs. In those receptors where desensitization occurs from the open state (or the one immediately preceding it), the method also enables us to determine the number of binding sites.

Original languageEnglish
Pages (from-to)963-986
Number of pages24
JournalBulletin of Mathematical Biology
Volume61
Issue number5
DOIs
StatePublished - Sep 1999

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