A three-station DNA catenane rotary motor with controlled directionality

Chun Hua Lu, Alessandro Cecconello, Johann Elbaz, Alberto Credi, Itamar Willner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

The assembly of DNA machines represents a central effort in DNA nanotechnology. We report on the first DNA rotor system composed of a two-ring catenane. The DNA rotor ring rotates in dictated directions along a wheel, and it occupies three distinct sites. Hg2+/cysteine or pH (H +/OH-) act as fuels or antifuels in positioning the rotor ring. Analysis of the kinetics reveals directional clockwise or anticlockwise population of the target-sites (>85%), and the rotor's direction is controlled by the shortest path on the wheel.

Original languageEnglish
Pages (from-to)2303-2308
Number of pages6
JournalNano Letters
Volume13
Issue number5
DOIs
StatePublished - 8 May 2013

Keywords

  • catenane
  • DNA
  • fluorescence resonance energy transfer (FRET)
  • machine
  • nanotechnology

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