TY - JOUR
T1 - A transmission disequilibrium and linkage analysis of D22S278 marker alleles in 574 families
T2 - Further support for a susceptibility locus for schizophrenia at 22q12
AU - Schizophrenia Collaborative Linkage Group for Chromosome 22
AU - Vallada, Homero P.
AU - Collier, David A.
AU - Curtis, David
AU - Sham, Pak C.
AU - Kunugi, Hiro
AU - Zhao, Jinghua
AU - Murray, Robin
AU - McGuffin, Peter
AU - Nanko, Shin
AU - Owen, Mike
AU - Gill, Michael
AU - Antonarakis, Stylianos
AU - Housman, David
AU - Kazazian, Haig
AU - Nestadt, Gerald
AU - Pulver, Ann E.
AU - Straub, Richard E.
AU - MacLean, Charles J.
AU - Walsh, Dermot
AU - Kendler, Kenneth S.
AU - DeLisi, Lyn
AU - Polymeropoulos, Mihael
AU - Coon, Hilary
AU - Byerley, William
AU - Lofthouse, Ray
AU - Gershon, Elliot
AU - Goldin, Lynn
AU - Freedman, Robert
AU - Laurent, Claudine
AU - Bodeau-Pean, Sylvie
AU - d'Amato, Thierry
AU - Jay, Maurice
AU - Campion, Dominique
AU - Mallet, Jacques
AU - Wildenauer, Dieter B.
AU - Lerer, Bernard
AU - Albus, Margot
AU - Ackenheil, Manfred
AU - Ebstein, Richard P.
AU - Hallmayer, Joachim
AU - Maier, Wolfgang
AU - Gurling, Hugh
AU - Kalsi, Gusharon
AU - Brynjolfsson, Jon
AU - Sigmundson, Thordur
AU - Petursson, Hannes
AU - Blackwood, Douglas
AU - Muir, Walter
AU - StClair, David
AU - He, Lin
PY - 1998/7/27
Y1 - 1998/7/27
N2 - Previously, a combined analysis by the Chromosome 22 Collaborative Linkage Group (1996; Am. J. Med Genet. 67, 40-45) used an affected sib-pair analysis of a single marker (D22S278) in 574 families multiply affected by schizophrenia and found some evidence for linkage (λ2 = 9.35, 1 df, p = 0.001), suggesting the presence of a disease locus nearby on chromosome 22q12. In order to further investigate the importance of this result, we have performed the transmission disequilibrium test (TDT) and additional parametric and non-parametric linkage analysis of the same data. The most positive result obtained was an admixture lod score of 0.9 under the assumption of locus heterogeneity and dominant transmission. The result of the TDT analysis was significant at p = 0.015 (allele-wise; λ2 = 22, 10 df) and p = 0.00016 (genotype-wise; λ2 = 66.2, 30 df, empirical p value = 0.0009). Overall, these results further strengthen the notion that there is a susceptibility locus for schizophrenia close to D22S278.
AB - Previously, a combined analysis by the Chromosome 22 Collaborative Linkage Group (1996; Am. J. Med Genet. 67, 40-45) used an affected sib-pair analysis of a single marker (D22S278) in 574 families multiply affected by schizophrenia and found some evidence for linkage (λ2 = 9.35, 1 df, p = 0.001), suggesting the presence of a disease locus nearby on chromosome 22q12. In order to further investigate the importance of this result, we have performed the transmission disequilibrium test (TDT) and additional parametric and non-parametric linkage analysis of the same data. The most positive result obtained was an admixture lod score of 0.9 under the assumption of locus heterogeneity and dominant transmission. The result of the TDT analysis was significant at p = 0.015 (allele-wise; λ2 = 22, 10 df) and p = 0.00016 (genotype-wise; λ2 = 66.2, 30 df, empirical p value = 0.0009). Overall, these results further strengthen the notion that there is a susceptibility locus for schizophrenia close to D22S278.
KW - Chromosome 22
KW - Combined analysis
KW - Complex disease genetics
KW - Psychosis
KW - TDT
UR - https://www.scopus.com/pages/publications/0032572612
U2 - 10.1016/S0920-9964(98)00048-6
DO - 10.1016/S0920-9964(98)00048-6
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C2 - 9713907
AN - SCOPUS:0032572612
SN - 0920-9964
VL - 32
SP - 115
EP - 121
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 2
ER -