A transplantable mouse tumor deficient in cyclic-AMP-dependent protein kinase activity

Jacob Hochman; Aviva Katz; Yacob Weinstein

doi:10.1016/0014-2964(79)90199-3

A transplantable mouse tumor deficient in cyclic-AMP-dependent protein kinase activity

Jacob Hochman^*, Aviva Katz, Yacob Weinstein

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

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Abstract

A transplantable solid tumor deficient in cyclic-AMP-dependent protein kinase (PK) (ATP: protein phosphotransferase; E.C.2.7.1.37) activity was established in vivo following injection into recipient nude mice of mutant (PK^-)S49 mouse lymphoma cells propagated in vitro in suspension culture. Tumor cell growth was not affected by dibutyryl cyclic AMP (DB-cAMP) when transferred back into culture. These results suggest that cyclic AMP (cAMP) is not essential for cellular growth both in vitro and in vivo. In addition it is suggested that the absence of cAMP dependent protein kinase is related to the tumorigenicity of the cells by rendering them less controlable by environmental stimuli in the host.

Original language	English
Pages (from-to)	11-13,15-16
Journal	European Journal of Cancer (1965)
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/0014-2964(79)90199-3
State	Published - Jan 1979

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abstract = "A transplantable solid tumor deficient in cyclic-AMP-dependent protein kinase (PK) (ATP: protein phosphotransferase; E.C.2.7.1.37) activity was established in vivo following injection into recipient nude mice of mutant (PK-)S49 mouse lymphoma cells propagated in vitro in suspension culture. Tumor cell growth was not affected by dibutyryl cyclic AMP (DB-cAMP) when transferred back into culture. These results suggest that cyclic AMP (cAMP) is not essential for cellular growth both in vitro and in vivo. In addition it is suggested that the absence of cAMP dependent protein kinase is related to the tumorigenicity of the cells by rendering them less controlable by environmental stimuli in the host.",

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A transplantable mouse tumor deficient in cyclic-AMP-dependent protein kinase activity

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