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A tribute to the 60 years of angioplasty celebrating January 16th, 1964’s first angioplasty by Charles Dotter: voices from the past, messages to build the future

  • Jean Marco
  • , Chiara de Biase
  • , Luigi Spadafora
  • , Emanuele Barbato
  • , Davide Capodanno
  • , Francesco Saia
  • , Salvatore de Rosa
  • , Elad Asher
  • , Mattia Galli
  • , Marco Bernardi*
  • , Pierre Sabouret
  • *Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Charles T. Dotter is a recognized pioneer of interventional cardiology as much as the inventor of the angioplasty balloon himself, Andreas R. Grüntzig. Yet, despite Dotter’s pioneering role in developing transluminal angioplasty, a recent survey revealed a significant lack of awareness among younger interventional cardiologists and fellows about his contributions, contrasting sharply with their familiarity with Grüntzig. We thereby shed light on Dotter’s innovations and the reasons behind his relative obscurity in contemporary discourse, urging the medical community to embrace the lessons from his journey for future success. We explicitly focus on Dotter’s early achievements, including his groundbreaking work in 1964, where he performed the first transluminal angioplasty, laying the groundwork for what would become a cornerstone in vascular intervention and creating the eponymous Dotter effect. Despite the initial resistance and skepticism, Dotter’s methods eventually found their way to Europe, influencing Grüntzig and leading to the development of the balloon catheter. We also meticulously trace the evolution of angioplasty from Dotter’s early experiments to Grüntzig’s refinement of the technique and its application in coronary arteries, underscoring the pivotal moments and challenges encountered along the way. Dotter’s obscurity stems from a combination of factors, including his confrontational approach and the reluctance of the medical establishment to embrace his radical ideas. Indeed, Dotter’s story offers invaluable lessons on the importance of teamwork, perseverance, and the need for a supportive community to foster innovation in medicine.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalMinerva Cardiology and Angiology
Volume74
Issue number2
DOIs
StatePublished - Apr 2026

Bibliographical note

Publisher Copyright:
© 2025 EDIZIONI MINERVA MEDICA.

Keywords

  • Andreas Grüntzig
  • Angioplasty
  • Charles Dotter
  • Interventional cardiology
  • Invasive cardiology

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