A Ubiquitous Platform for Bacterial Nanotube Biogenesis

Saurabh Bhattacharya; Amit K. Baidya; Ritesh Ranjan Pal; Gideon Mamou; Yair E. Gatt; Hanah Margalit; Ilan Rosenshine; Sigal Ben-Yehuda

doi:10.1016/j.celrep.2019.02.055

A Ubiquitous Platform for Bacterial Nanotube Biogenesis

Saurabh Bhattacharya, Amit K. Baidya, Ritesh Ranjan Pal, Gideon Mamou, Yair E. Gatt, Hanah Margalit, Ilan Rosenshine^*, Sigal Ben-Yehuda

^*Corresponding author for this work

Department of Microbiology and Molecular Genetics

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Bhattacharya et al. show that bacterial intercellular nanotubes, facilitating cytoplasmic molecular exchange among cells, emerge from conserved CORE components of the flagellar export apparatus. CORE-mediated nanotube formation is widespread among bacterial species. The results establish the CORE-derived nanotube as a ubiquitous organelle, facilitating intercellular molecular trafficking across the bacterial kingdom.

Original language	American English
Pages (from-to)	334-342.e10
Journal	Cell Reports
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2019.02.055
State	Published - 9 Apr 2019

Bibliographical note

Funding Information:
We thank E. Blayvas and A. Ben-Hur (Hebrew University) for help with XHR-SEM and R. Nir-Paz (Hadassah Hospital) and A. Herskovits (Tel Aviv University) for strains and plasmids. We are grateful to S. Wagner (Tubingen University) for help generating Figure 4 E and valuable insight. We are indebted to A. Rouvinski (Hebrew University) and members of the Ben-Yehuda and Rosenshine laboratories for valuable discussions. This work was supported by a European Research Council Advance grant ( 339984 ) awarded to S.B.-Y.; a grant from the Israel Science Foundation ( 617/15 ) awarded to I.R.; a European Research Council Synergy grant ( 810186 ) awarded to S.B.-Y. and I.R.; and a grant from the Israel Science Foundation ( 876/17 ) awarded to H.M. S.B. is partially funded by the Lady Davis Fellowship Trust , and Y.E.G. is partially supported by the Hoffman Program .

Publisher Copyright:
© 2019 The Author(s)

Keywords

Bacillus subtilis
bacterial communication
bacterial community
contact-dependent molecular exchange
flagella type III secretion system
flagellar export apparatus
nanotubes

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10.1016/j.celrep.2019.02.055

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title = "A Ubiquitous Platform for Bacterial Nanotube Biogenesis",

abstract = "Bhattacharya et al. show that bacterial intercellular nanotubes, facilitating cytoplasmic molecular exchange among cells, emerge from conserved CORE components of the flagellar export apparatus. CORE-mediated nanotube formation is widespread among bacterial species. The results establish the CORE-derived nanotube as a ubiquitous organelle, facilitating intercellular molecular trafficking across the bacterial kingdom.",

keywords = "Bacillus subtilis, bacterial communication, bacterial community, contact-dependent molecular exchange, flagella type III secretion system, flagellar export apparatus, nanotubes",

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AU - Margalit, Hanah

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AU - Ben-Yehuda, Sigal

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A Ubiquitous Platform for Bacterial Nanotube Biogenesis

Abstract

Bibliographical note

Keywords

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