A Ubiquitous Platform for Bacterial Nanotube Biogenesis

Saurabh Bhattacharya, Amit K. Baidya, Ritesh Ranjan Pal, Gideon Mamou, Yair E. Gatt, Hanah Margalit, Ilan Rosenshine*, Sigal Ben-Yehuda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Bhattacharya et al. show that bacterial intercellular nanotubes, facilitating cytoplasmic molecular exchange among cells, emerge from conserved CORE components of the flagellar export apparatus. CORE-mediated nanotube formation is widespread among bacterial species. The results establish the CORE-derived nanotube as a ubiquitous organelle, facilitating intercellular molecular trafficking across the bacterial kingdom.

Original languageAmerican English
Pages (from-to)334-342.e10
JournalCell Reports
Issue number2
StatePublished - 9 Apr 2019

Bibliographical note

Funding Information:
We thank E. Blayvas and A. Ben-Hur (Hebrew University) for help with XHR-SEM and R. Nir-Paz (Hadassah Hospital) and A. Herskovits (Tel Aviv University) for strains and plasmids. We are grateful to S. Wagner (Tubingen University) for help generating Figure 4 E and valuable insight. We are indebted to A. Rouvinski (Hebrew University) and members of the Ben-Yehuda and Rosenshine laboratories for valuable discussions. This work was supported by a European Research Council Advance grant ( 339984 ) awarded to S.B.-Y.; a grant from the Israel Science Foundation ( 617/15 ) awarded to I.R.; a European Research Council Synergy grant ( 810186 ) awarded to S.B.-Y. and I.R.; and a grant from the Israel Science Foundation ( 876/17 ) awarded to H.M. S.B. is partially funded by the Lady Davis Fellowship Trust , and Y.E.G. is partially supported by the Hoffman Program .

Publisher Copyright:
© 2019 The Author(s)


  • Bacillus subtilis
  • bacterial communication
  • bacterial community
  • contact-dependent molecular exchange
  • flagella type III secretion system
  • flagellar export apparatus
  • nanotubes


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