Bhattacharya et al. show that bacterial intercellular nanotubes, facilitating cytoplasmic molecular exchange among cells, emerge from conserved CORE components of the flagellar export apparatus. CORE-mediated nanotube formation is widespread among bacterial species. The results establish the CORE-derived nanotube as a ubiquitous organelle, facilitating intercellular molecular trafficking across the bacterial kingdom.
Bibliographical noteFunding Information:
We thank E. Blayvas and A. Ben-Hur (Hebrew University) for help with XHR-SEM and R. Nir-Paz (Hadassah Hospital) and A. Herskovits (Tel Aviv University) for strains and plasmids. We are grateful to S. Wagner (Tubingen University) for help generating Figure 4 E and valuable insight. We are indebted to A. Rouvinski (Hebrew University) and members of the Ben-Yehuda and Rosenshine laboratories for valuable discussions. This work was supported by a European Research Council Advance grant ( 339984 ) awarded to S.B.-Y.; a grant from the Israel Science Foundation ( 617/15 ) awarded to I.R.; a European Research Council Synergy grant ( 810186 ) awarded to S.B.-Y. and I.R.; and a grant from the Israel Science Foundation ( 876/17 ) awarded to H.M. S.B. is partially funded by the Lady Davis Fellowship Trust , and Y.E.G. is partially supported by the Hoffman Program .
© 2019 The Author(s)
- Bacillus subtilis
- bacterial communication
- bacterial community
- contact-dependent molecular exchange
- flagella type III secretion system
- flagellar export apparatus