A zinc selective oxytocin based biosensor

Evgeniy Mervinetsky, Israel Alshanski, Kiran Kumar Tadi, Mattan Hurevich, Shlomo Yitzchaik, Arezoo Dianat, Jörg Buchwald, Rafael Gutierrez*, Gianaurelio Cuniberti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Oxytocin is a peptide hormone with high affinity to both Zn2+ and Cu2+ ions compared to other metal ions. This affinity makes oxytocin an attractive recognition layer for monitoring the levels of these essential ions in biofluids. Native oxytocin cannot differentiate between Cu2+ and Zn2+ ions and hence it is not useful for sensing Zn2+ in the presence of Cu2+. We elucidated the effect of the terminal amine group of oxytocin on the affinity toward Cu2+ using theoretical calculations. We designed a new Zn2+ selective oxytocin-based biosensor that utilizes the terminal amine for surface anchoring, also preventing the response to Cu2+. The biosensor shows exceptional selectivity and very high sensitivity to Zn2+ in impedimetric biosensing.

Original languageAmerican English
Pages (from-to)155-160
Number of pages6
JournalJournal of Materials Chemistry B
Volume8
Issue number1
DOIs
StatePublished - 1 Jan 2020

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This journal is © The Royal Society of Chemistry.

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