Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection

R. Wallich; N. Bulbuc; G. J. Hämmerling; S. Katzav; S. Segal; M. Feldman

doi:10.1038/315301a0

Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection

R. Wallich^*
, N. Bulbuc
, G. J. Hämmerling
, S. Katzav
, S. Segal
, M. Feldman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

385 Scopus citations

Abstract

H-2 gene transfection was used to restore expression of H-2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H-2K antigens. De novo expression of H-2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H-2K may lead to effective recognition of the disseminating tumour cells by the host immune system.

Original language	English
Pages (from-to)	301-305
Number of pages	5
Journal	Nature
Volume	315
Issue number	6017
DOIs	https://doi.org/10.1038/315301a0
State	Published - 1985
Externally published	Yes

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abstract = "H-2 gene transfection was used to restore expression of H-2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H-2K antigens. De novo expression of H-2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H-2K may lead to effective recognition of the disseminating tumour cells by the host immune system.",

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T1 - Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection

AU - Wallich, R.

AU - Bulbuc, N.

AU - Hämmerling, G. J.

AU - Katzav, S.

AU - Segal, S.

AU - Feldman, M.

PY - 1985

Y1 - 1985

N2 - H-2 gene transfection was used to restore expression of H-2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H-2K antigens. De novo expression of H-2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H-2K may lead to effective recognition of the disseminating tumour cells by the host immune system.

AB - H-2 gene transfection was used to restore expression of H-2K antigens in metastatic and non-metastatic subclones of a murine fibrosarcoma that lack their major histocompatibility complex-encoded H-2K antigens. De novo expression of H-2K reduced tumorigenicity and abolished the formation of metastasis in syngeneic mice. Expression of H-2K may lead to effective recognition of the disseminating tumour cells by the host immune system.

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Abrogation of metastatic properties of tumour cells by de novo expression of H-2K antigens following H-2 gene transfection

Abstract

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