Absence of microsatellite instability during the progression of chronic myelocytic leukemia

N. Mori*, S. Takeuchi, T. Tasaka, S. Lee, S. Spira, D. Ben-Yehuda, H. Mizoguchi, G. Schiller, H. P. Koeffler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed throughout the genome. To test the occurrence of genetic instability in the progression of chronic myelocytic leukemia (CML), we studied microsatellite instability (MSI) in 17 patients with CML. The DNAs from both chronic phase and blast crisis were analyzed at 10 loci. No MSI was observed in any of the 17 cases of blast crisis. These results indicate that MSI is rare and is not associated with progression to blast crisis in most cases of CML.

Original languageAmerican English
Pages (from-to)151-152
Number of pages2
JournalLeukemia
Volume11
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported in part by grants from the NIH, the Concern Foundation and the Parker Hughes Trust.

Keywords

  • Chronic myelocytic leukemia
  • Microsatellite instability
  • Mismatch repair

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