Absence of microsatellite instability during the progression of chronic myelocytic leukemia

N. Mori; S. Takeuchi; T. Tasaka; S. Lee; S. Spira; D. Ben-Yehuda; H. Mizoguchi; G. Schiller; H. P. Koeffler

doi:10.1038/sj.leu.2400524

Absence of microsatellite instability during the progression of chronic myelocytic leukemia

N. Mori^*, S. Takeuchi, T. Tasaka, S. Lee, S. Spira, D. Ben-Yehuda, H. Mizoguchi, G. Schiller, H. P. Koeffler

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed throughout the genome. To test the occurrence of genetic instability in the progression of chronic myelocytic leukemia (CML), we studied microsatellite instability (MSI) in 17 patients with CML. The DNAs from both chronic phase and blast crisis were analyzed at 10 loci. No MSI was observed in any of the 17 cases of blast crisis. These results indicate that MSI is rare and is not associated with progression to blast crisis in most cases of CML.

Original language	English
Pages (from-to)	151-152
Number of pages	2
Journal	Leukemia
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/sj.leu.2400524
State	Published - 1997
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported in part by grants from the NIH, the Concern Foundation and the Parker Hughes Trust.

Keywords

Chronic myelocytic leukemia
Microsatellite instability
Mismatch repair

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.leu.2400524

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title = "Absence of microsatellite instability during the progression of chronic myelocytic leukemia",

abstract = "Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed throughout the genome. To test the occurrence of genetic instability in the progression of chronic myelocytic leukemia (CML), we studied microsatellite instability (MSI) in 17 patients with CML. The DNAs from both chronic phase and blast crisis were analyzed at 10 loci. No MSI was observed in any of the 17 cases of blast crisis. These results indicate that MSI is rare and is not associated with progression to blast crisis in most cases of CML.",

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doi = "10.1038/sj.leu.2400524",

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T1 - Absence of microsatellite instability during the progression of chronic myelocytic leukemia

AU - Mori, N.

AU - Takeuchi, S.

AU - Tasaka, T.

AU - Lee, S.

AU - Spira, S.

AU - Ben-Yehuda, D.

AU - Mizoguchi, H.

AU - Schiller, G.

AU - Koeffler, H. P.

N1 - Funding Information: This work was supported in part by grants from the NIH, the Concern Foundation and the Parker Hughes Trust.

PY - 1997

Y1 - 1997

N2 - Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed throughout the genome. To test the occurrence of genetic instability in the progression of chronic myelocytic leukemia (CML), we studied microsatellite instability (MSI) in 17 patients with CML. The DNAs from both chronic phase and blast crisis were analyzed at 10 loci. No MSI was observed in any of the 17 cases of blast crisis. These results indicate that MSI is rare and is not associated with progression to blast crisis in most cases of CML.

AB - Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed throughout the genome. To test the occurrence of genetic instability in the progression of chronic myelocytic leukemia (CML), we studied microsatellite instability (MSI) in 17 patients with CML. The DNAs from both chronic phase and blast crisis were analyzed at 10 loci. No MSI was observed in any of the 17 cases of blast crisis. These results indicate that MSI is rare and is not associated with progression to blast crisis in most cases of CML.

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KW - Microsatellite instability

KW - Mismatch repair

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Absence of microsatellite instability during the progression of chronic myelocytic leukemia

Abstract

Bibliographical note

Keywords

UN SDGs

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