Absence of rearrangements in the BRCA2 gene in human cancers

S. F. Chin; Q. Wang; A. Puisieux; C. Caldas

doi:10.1054/bjoc.2000.1577

Absence of rearrangements in the BRCA2 gene in human cancers

S. F. Chin
, Q. Wang
, A. Puisieux
, C. Caldas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Mutations of BRCA2 in sporadic breast and ovarian carcinomas are exceedingly rare. This led to the suggestion that large genomic rearrangements could be involved. We performed Southern blots in genomic DNA from 130 primary breast cancers and 83 cancer cell lines (breast, ovarian, pancreatic and small cell lung carcinomas) and found no genomic rearrangements. These results suggest that a gene other than BRCA2 is the target of the frequent 13q12.3 allelic deletions in human cancers.

Original language	English
Pages (from-to)	193-195
Number of pages	3
Journal	British Journal of Cancer
Volume	84
Issue number	2
DOIs	https://doi.org/10.1054/bjoc.2000.1577
State	Published - 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

BRCA2
Deletion
Human cancers
Rearrangement
Southern blot

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10.1054/bjoc.2000.1577

Cite this

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abstract = "Mutations of BRCA2 in sporadic breast and ovarian carcinomas are exceedingly rare. This led to the suggestion that large genomic rearrangements could be involved. We performed Southern blots in genomic DNA from 130 primary breast cancers and 83 cancer cell lines (breast, ovarian, pancreatic and small cell lung carcinomas) and found no genomic rearrangements. These results suggest that a gene other than BRCA2 is the target of the frequent 13q12.3 allelic deletions in human cancers.",

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AU - Caldas, C.

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AB - Mutations of BRCA2 in sporadic breast and ovarian carcinomas are exceedingly rare. This led to the suggestion that large genomic rearrangements could be involved. We performed Southern blots in genomic DNA from 130 primary breast cancers and 83 cancer cell lines (breast, ovarian, pancreatic and small cell lung carcinomas) and found no genomic rearrangements. These results suggest that a gene other than BRCA2 is the target of the frequent 13q12.3 allelic deletions in human cancers.

KW - BRCA2

KW - Deletion

KW - Human cancers

KW - Rearrangement

KW - Southern blot

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Absence of rearrangements in the BRCA2 gene in human cancers

Abstract

UN SDGs

Keywords

Access to Document

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