Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera from Individuals with Recent Seasonal Coronavirus Infection

Daniel Poston, Yiska Weisblum, Helen Wise, Kate Templeton, Sara Jenks, Theodora Hatziioannou, Paul Bieniasz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

Original languageEnglish
Pages (from-to)E1208-E1211
JournalClinical Infectious Diseases
Volume73
Issue number5
DOIs
StatePublished - 1 Sep 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

Keywords

  • antibodies
  • COVID-19
  • neutralization
  • SARS-CoV-2
  • seasonal coronavirus

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