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Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera from Individuals with Recent Seasonal Coronavirus Infection

  • Daniel Poston
  • , Yiska Weisblum
  • , Helen Wise
  • , Kate Templeton
  • , Sara Jenks
  • , Theodora Hatziioannou
  • , Paul Bieniasz*
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

Original languageEnglish
Pages (from-to)E1208-E1211
JournalClinical Infectious Diseases
Volume73
Issue number5
DOIs
StatePublished - 1 Sep 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2020 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • COVID-19
  • SARS-CoV-2
  • antibodies
  • neutralization
  • seasonal coronavirus

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