Absorption of Orally Administered Digoxin After Massive Resection of the Small Bowel

MICHAEL M. Krausz*, Elliot Berry, Uri Freund, Micha Levy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Digoxin absorption was studied in a patient after massive small bowel resection (with only 15 cm. of jejunum left) after mesenteric thrombosis. Oral administration of 0.25 mg. digoxin tablets resulted in therapeutic blood levels between 0.7 and 2.2 ng./ml. Measurement of the urinary excretion of the drug in steady state revealed more than 80% of the maintenance dose. Renal digoxin clearance was 125 ml./min. This resulted in showing of the heart rate from 120 to 80/min. with no side‐effects. It is thus concluded that total absorption of digoxin might be normal in a patient with only 15 cm. of jejunum and that usual dogs of digoxin were sufficient for a therapeutic effect and “therapeutic” blood levels.

Original languageEnglish
Pages (from-to)220-223
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume71
Issue number2
DOIs
StatePublished - Feb 1979

Fingerprint

Dive into the research topics of 'Absorption of Orally Administered Digoxin After Massive Resection of the Small Bowel'. Together they form a unique fingerprint.

Cite this