Accelerated Multiphosphorylated Peptide Synthesis

Dana Grunhaus, Estefanía Rossich Molina, Roni Cohen, Tamar Stein, Assaf Friedler*, Mattan Hurevich*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Preparing phosphorylated peptides with multiple adjacent phosphorylations is synthetically difficult, leads to β-elimination, results in low yields, and is extremely slow. We combined synthetic chemical methodologies with computational studies and engineering approaches to develop a strategy that takes advantage of fast stirring, high temperature, and a very low concentration of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to produce multiphosphorylated peptides at an extremely rapid time and high purity.

Original languageAmerican English
Pages (from-to)2492-2497
Number of pages6
JournalOrganic Process Research and Development
Issue number8
StatePublished - 19 Aug 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors. Published by American Chemical Society.


  • acceleration
  • kinetics
  • peptide
  • phosphorylation
  • solid phase synthesis


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