Accidental fatal aflatoxicosis due to contaminated commercial diet in 50 dogs

Y. Bruchim*, G. Segev, U. Sela, T. Bdolah-Abram, A. Salomon, I. Aroch

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Aflatoxins, produced by Aspergillus spp., are toxic contaminants of stored grain. This study describes 50 dogs presented with foodborne aflatoxicosis. Common clinical signs included lethargy (78%), vomiting (76%), anorexia (74%), icterus (66%), depression (66%), melena (60%), haematuria (36%) and diarrhoea (36%). Common laboratory abnormalities included increased activities of aspartate aminotransferase (86%), alkaline phosphatase (84%) and alanine aminotransferase (79%), hypoantithrombinaemia (86%), prolonged prothrombin (PT, 82%) and activated partial thromboplastin times (aPTT, 80%), hyperbilirubinaemia (73%), hypocholesterolaemia (60%) hypoalbuminemia (47%) and thrombocytopenia (42%). Non-survivors had longer PT and aPTT and lower antithrombin (P< 0.001) at presentation compared to survivors (23.8. s vs.10.5; 37.9 vs.17.6s and 5% vs. 54%, respectively). Hyperbilirubinaemia (>56.6 μmol/L) and albumin concentration <32.5. g/L at presentation were risk factors for mortality (P< 0.0001). Common complications included disseminated intravascular coagulation (58%), hepatic encephalopathy (35%) and acute kidney injury (4%). The mortality rate was 68%, suggesting that dogs with aflatoxicosis have poor prognosis.

Original languageAmerican English
Pages (from-to)279-287
Number of pages9
JournalResearch in Veterinary Science
Volume93
Issue number1
DOIs
StatePublished - Aug 2012

Keywords

  • Aflatoxin
  • Canine
  • Disseminated intravascular coagulation
  • Intoxication
  • Liver failure

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