Accumulation of F-spondin in injured peripheral nerve promotes the outgrowth of sensory axons

Tal Burstyn-Cohen, Ayala Frumkin, Yi Tian Xu, Steven S. Scherer, Avihu Klar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

F-spondin, an extracellular matrix protein, is present in peripheral nerve during embryonic development, but its amount diminishes by birth. Axotomy of adult rat sciatic nerve, however, causes a massive upregulation of both F-spondin mRNA and protein distal to the lesion. F-spondin in the distal stump of axotomized nerve promotes neurite outgrowth of sensory neurons, as revealed by protein neutralization with F-spondin-specific antibodies. Thus, F-spondin is likely to play a role in promoting axonal regeneration after nerve injury.

Original languageAmerican English
Pages (from-to)8875-8885
Number of pages11
JournalJournal of Neuroscience
Volume18
Issue number21
DOIs
StatePublished - 1 Nov 1998

Keywords

  • Extracellular matrix
  • F-spondin
  • Nerve regeneration
  • Neurite outgrowth
  • Schwann cells
  • Sensory axons

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