Abstract
F-spondin, an extracellular matrix protein, is present in peripheral nerve during embryonic development, but its amount diminishes by birth. Axotomy of adult rat sciatic nerve, however, causes a massive upregulation of both F-spondin mRNA and protein distal to the lesion. F-spondin in the distal stump of axotomized nerve promotes neurite outgrowth of sensory neurons, as revealed by protein neutralization with F-spondin-specific antibodies. Thus, F-spondin is likely to play a role in promoting axonal regeneration after nerve injury.
Original language | English |
---|---|
Pages (from-to) | 8875-8885 |
Number of pages | 11 |
Journal | Journal of Neuroscience |
Volume | 18 |
Issue number | 21 |
DOIs | |
State | Published - 1 Nov 1998 |
Keywords
- Extracellular matrix
- F-spondin
- Nerve regeneration
- Neurite outgrowth
- Schwann cells
- Sensory axons