Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures

Orit Chai*, Adi Sommer, Gabriel Zimmerman, Hermona Soreq, Alon Friedman, Tali Bdolah-Abram, Itamar Aroch, Merav H. Shamir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Recent studies in animal models have focused on the role of cholinergic elements, mainly acetylcholinesterase (AChE) and the 'readthrough' acetylcholinesterase isoform (AChE-R), in seizures. A prospective double-masked study was conducted to assess the activity of AChE and AChE-R in cerebrospinal fluid (CSF) of 26 dogs post-seizure, 28 dogs with intervertebral disc disease (IVDD) and 16 healthy dogs. AChE was also measured in the serum in the post-seizure and IVDD groups. The results showed no significant differences in CSF AChE among the three groups. AChE-R was not detected in any dog and AChE in the serum was similar between groups. This preliminary study provides new information on AChE and AChE-R in the CSF and sera of dogs following naturally-occurring seizures.

Original languageAmerican English
Pages (from-to)292-294
Number of pages3
JournalVeterinary Journal
Issue number1
StatePublished - Oct 2013

Bibliographical note

Funding Information:
This study was supported by a grant from the Ministry of Health in Israel.


  • Acetylcholinesterase
  • Cerebrospinal fluid
  • Dog
  • Epilepsy
  • Readthrough acetylcholinesterase


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