Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures

Orit Chai; Adi Sommer; Gabriel Zimmerman; Hermona Soreq; Alon Friedman; Tali Bdolah-Abram; Itamar Aroch; Merav H. Shamir

doi:10.1016/j.tvjl.2013.06.027

Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures

Orit Chai^*, Adi Sommer, Gabriel Zimmerman, Hermona Soreq, Alon Friedman, Tali Bdolah-Abram, Itamar Aroch, Merav H. Shamir

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Recent studies in animal models have focused on the role of cholinergic elements, mainly acetylcholinesterase (AChE) and the 'readthrough' acetylcholinesterase isoform (AChE-R), in seizures. A prospective double-masked study was conducted to assess the activity of AChE and AChE-R in cerebrospinal fluid (CSF) of 26 dogs post-seizure, 28 dogs with intervertebral disc disease (IVDD) and 16 healthy dogs. AChE was also measured in the serum in the post-seizure and IVDD groups. The results showed no significant differences in CSF AChE among the three groups. AChE-R was not detected in any dog and AChE in the serum was similar between groups. This preliminary study provides new information on AChE and AChE-R in the CSF and sera of dogs following naturally-occurring seizures.

Original language	English
Pages (from-to)	292-294
Number of pages	3
Journal	Veterinary Journal
Volume	198
Issue number	1
DOIs	https://doi.org/10.1016/j.tvjl.2013.06.027
State	Published - Oct 2013

Bibliographical note

Funding Information:
This study was supported by a grant from the Ministry of Health in Israel.

Keywords

Acetylcholinesterase
Cerebrospinal fluid
Dog
Epilepsy
Readthrough acetylcholinesterase

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10.1016/j.tvjl.2013.06.027

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title = "Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures",

abstract = "Recent studies in animal models have focused on the role of cholinergic elements, mainly acetylcholinesterase (AChE) and the 'readthrough' acetylcholinesterase isoform (AChE-R), in seizures. A prospective double-masked study was conducted to assess the activity of AChE and AChE-R in cerebrospinal fluid (CSF) of 26 dogs post-seizure, 28 dogs with intervertebral disc disease (IVDD) and 16 healthy dogs. AChE was also measured in the serum in the post-seizure and IVDD groups. The results showed no significant differences in CSF AChE among the three groups. AChE-R was not detected in any dog and AChE in the serum was similar between groups. This preliminary study provides new information on AChE and AChE-R in the CSF and sera of dogs following naturally-occurring seizures.",

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author = "Orit Chai and Adi Sommer and Gabriel Zimmerman and Hermona Soreq and Alon Friedman and Tali Bdolah-Abram and Itamar Aroch and Shamir, {Merav H.}",

note = "Funding Information: This study was supported by a grant from the Ministry of Health in Israel.",

year = "2013",

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doi = "10.1016/j.tvjl.2013.06.027",

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AU - Friedman, Alon

AU - Bdolah-Abram, Tali

AU - Aroch, Itamar

AU - Shamir, Merav H.

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Acetylcholinesterase activity in the cerebrospinal fluid of dogs with seizures

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Bibliographical note

Keywords

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