Acetylcholinesterase of Schistosoma mansoni: antigenic cross‐reactivity with Electrophorus electricus and its functional implications

Rebecca Tarrab‐Hazdai*, Francesca Levi‐Schaffer, Moshe Smolarsky, Ruth Arnon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Acetylcholinesterase (AChE) of the parasite Schistosoma mansoni cross‐reacts with rabbit antibodies against AChE from the electric eel. Cross‐reactivity was demonstrated by radioimmunoassay with sonicate, as well as soluble, preparations from various stages of the parasite life cycle. On sucrose density gradient, the parasite enzyme migrates as an 7.5 S form, whereas an 9.5 S peak is observed with the enzyme‐antibody complex. Immunofluorescence microscopy shows specific staining of intact schistosomula as well as of adult worms. Moreover, the interaction of these antibodies resulted in a marked complement‐dependent cytotoxicity towards intact schistosomula, indicating that AChE is an antigen of significance on the surface of the parasite.

Original languageAmerican English
Pages (from-to)205-209
Number of pages5
JournalEuropean Journal of Immunology
Volume14
Issue number3
DOIs
StatePublished - 1984
Externally publishedYes

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