Activating endogenous opioid systems by electroconvulsive shock or footshock stress inhibits recurrent kindled seizures in rats

Yehuda Shavit, Sally Caldecott-Hazard, John C. Liebeskind*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Electroconvulsive shock (ECS) significantly decreased the behavioral manifestations of seizures elicited by amygdaloid stimulation in kindled rats. This anticonvulsant effect was significantly reduced by the opiate antagonist, naloxone, and by the development of morphine tolerance. A form of footshock stress known to cause opioid-mediated analgesia had a similar anticonvulsant effect, whereas another form causing non-opioid analgesia did not. These results suggest that the anticonvulsant effects of ECS and stress are mediated by the release of endogenous opioids.

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalBrain Research
Volume305
Issue number2
DOIs
StatePublished - 9 Jul 1984
Externally publishedYes

Keywords

  • anticonvulsant effect
  • electroconvulsive shock
  • endogenous opioids
  • footshock stress
  • kindled seizures
  • morphine tolerance
  • naloxone

Fingerprint

Dive into the research topics of 'Activating endogenous opioid systems by electroconvulsive shock or footshock stress inhibits recurrent kindled seizures in rats'. Together they form a unique fingerprint.

Cite this