Activation of myelinated afferents ending in a neuroma by stimulation of the sympathetic supply in the rat

Marshall Devor; Wilfrid Jänig

doi:10.1016/0304-3940(81)90356-6

Activation of myelinated afferents ending in a neuroma by stimulation of the sympathetic supply in the rat

Marshall Devor, Wilfrid Jänig^*

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

221 Scopus citations

Abstract

The sciatic nerve in rats was cut and ligated, and 5-18 days later pathophysiological properties of the resulting neuroma were studied. We found that afferent fibers ending in the neuroma produced prolonged discharges following repetitive stimulation of the lumbar sympathetic trunk (LST) or i.v. adrenaline. Mean latencies of activation of afferent fibers were 10 ± 2.1 sec and 12 ± 3.4 sec (mean ± S.D.) to LST stimulation and to adrenaline injection, respectively. The α-adrenergic antagonist phentolamine blocked responses to LST stimulation and adrenaline. The β-adrenergic antagonist propranolol had no effect.

Original language	English
Pages (from-to)	43-47
Number of pages	5
Journal	Neuroscience Letters
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(81)90356-6
State	Published - 12 Jun 1981

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title = "Activation of myelinated afferents ending in a neuroma by stimulation of the sympathetic supply in the rat",

abstract = "The sciatic nerve in rats was cut and ligated, and 5-18 days later pathophysiological properties of the resulting neuroma were studied. We found that afferent fibers ending in the neuroma produced prolonged discharges following repetitive stimulation of the lumbar sympathetic trunk (LST) or i.v. adrenaline. Mean latencies of activation of afferent fibers were 10 ± 2.1 sec and 12 ± 3.4 sec (mean ± S.D.) to LST stimulation and to adrenaline injection, respectively. The α-adrenergic antagonist phentolamine blocked responses to LST stimulation and adrenaline. The β-adrenergic antagonist propranolol had no effect.",

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AB - The sciatic nerve in rats was cut and ligated, and 5-18 days later pathophysiological properties of the resulting neuroma were studied. We found that afferent fibers ending in the neuroma produced prolonged discharges following repetitive stimulation of the lumbar sympathetic trunk (LST) or i.v. adrenaline. Mean latencies of activation of afferent fibers were 10 ± 2.1 sec and 12 ± 3.4 sec (mean ± S.D.) to LST stimulation and to adrenaline injection, respectively. The α-adrenergic antagonist phentolamine blocked responses to LST stimulation and adrenaline. The β-adrenergic antagonist propranolol had no effect.

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Activation of myelinated afferents ending in a neuroma by stimulation of the sympathetic supply in the rat

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