Active cytotoxic reagents based on non-metallocene non-diketonato well-defined C2-symmetrical titanium complexes of tetradentate bis(phenolato) ligands

Michal Shavit; Dani Peri; Cesar M. Manna; Jacob S. Alexander; Edit Y. Tshuva

doi:10.1021/ja0753086

Active cytotoxic reagents based on non-metallocene non-diketonato well-defined C₂-symmetrical titanium complexes of tetradentate bis(phenolato) ligands

Michal Shavit, Dani Peri, Cesar M. Manna, Jacob S. Alexander, Edit Y. Tshuva^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

A new family of non-Cp-based non-diketonato-based C₂-symmetrical octahedral Ti(IV) complexes of dianionic diamine bis(phenolato) ligands, which are conveniently obtained as single isomers in quantitative yields, leads to appreciable cytotoxicity against colon and ovarian cells with a non-transferrin-dependent cell penetration mechanism. The ligand structural features including steric demands, symmetry, and aromaticity strongly influence activity, supporting its role in the biological mechanism of action.

Original language	English
Pages (from-to)	12098-12099
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	40
DOIs	https://doi.org/10.1021/ja0753086
State	Published - 10 Oct 2007

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title = "Active cytotoxic reagents based on non-metallocene non-diketonato well-defined C2-symmetrical titanium complexes of tetradentate bis(phenolato) ligands",

abstract = "A new family of non-Cp-based non-diketonato-based C2-symmetrical octahedral Ti(IV) complexes of dianionic diamine bis(phenolato) ligands, which are conveniently obtained as single isomers in quantitative yields, leads to appreciable cytotoxicity against colon and ovarian cells with a non-transferrin-dependent cell penetration mechanism. The ligand structural features including steric demands, symmetry, and aromaticity strongly influence activity, supporting its role in the biological mechanism of action.",

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AU - Shavit, Michal

AU - Peri, Dani

AU - Manna, Cesar M.

AU - Alexander, Jacob S.

AU - Tshuva, Edit Y.

PY - 2007/10/10

Y1 - 2007/10/10

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AB - A new family of non-Cp-based non-diketonato-based C2-symmetrical octahedral Ti(IV) complexes of dianionic diamine bis(phenolato) ligands, which are conveniently obtained as single isomers in quantitative yields, leads to appreciable cytotoxicity against colon and ovarian cells with a non-transferrin-dependent cell penetration mechanism. The ligand structural features including steric demands, symmetry, and aromaticity strongly influence activity, supporting its role in the biological mechanism of action.

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Active cytotoxic reagents based on non-metallocene non-diketonato well-defined C₂-symmetrical titanium complexes of tetradentate bis(phenolato) ligands

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