Active cytotoxic reagents based on non-metallocene non-diketonato well-defined C2-symmetrical titanium complexes of tetradentate bis(phenolato) ligands

Michal Shavit, Dani Peri, Cesar M. Manna, Jacob S. Alexander, Edit Y. Tshuva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

A new family of non-Cp-based non-diketonato-based C2-symmetrical octahedral Ti(IV) complexes of dianionic diamine bis(phenolato) ligands, which are conveniently obtained as single isomers in quantitative yields, leads to appreciable cytotoxicity against colon and ovarian cells with a non-transferrin-dependent cell penetration mechanism. The ligand structural features including steric demands, symmetry, and aromaticity strongly influence activity, supporting its role in the biological mechanism of action.

Original languageAmerican English
Pages (from-to)12098-12099
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number40
DOIs
StatePublished - 10 Oct 2007

Fingerprint

Dive into the research topics of 'Active cytotoxic reagents based on non-metallocene non-diketonato well-defined C2-symmetrical titanium complexes of tetradentate bis(phenolato) ligands'. Together they form a unique fingerprint.

Cite this