Active immunization of rats with a cell-free extract of the erythrocytic parasites of Plasmodium berghei

Avivah Zuckerman*, Joseph Hamburger, Dan Spira

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Weanling rats were vaccinated with a nonliving product prepared by grinding erythrocytic forms of Plasmodium berghei, liberated from their red-cell hosts by treatment with saponin. Vaccinated and control rats were then exposed to viable P. berghei. Infections in vaccinated rats were milder than in controls in that the prepatent period was lengthened, the patent period was curtailed, the peak parasitemias and cumulative parasite counts were reduced, and the mortality rates fell. The relation of these results to the vaccination of other hosts to their homologous plasmodia is discussed.

Original languageEnglish
Pages (from-to)84-97
Number of pages14
JournalExperimental Parasitology
Volume21
Issue number1
DOIs
StatePublished - Aug 1967

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