Active Src elevates the expression of β-catenin by enhancement of cap-dependent translation

Rotem Karni, Yael Gus, Yuval Dor, Oded Meyuhas, Alexander Levitzki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

The proto-oncogene pp60c-Src (c-Src) is activated in many types of cancer and contributes to the transformed phenotype of the tumor, although its role is not yet fully understood. Here we report that active Src elevates the levels of β-catenin by enhancing cap-dependent translation. Src induces phosphorylation of the eukaryotic initiation factor 4E via the Ras/Raf/ERK pathway and the phosphorylation of its inhibitor 4E-BP1 via the PI3K/mTOR pathway. Activated Src enhances the accumulation of nuclear β-catenin and enhances its transcriptional activity, elevating target genes such as cyclin D1. This novel activation of the Wnt pathway by Src most probably contributes to the oncogenic phenotype of cancer cells.

Original languageAmerican English
Pages (from-to)5031-5039
Number of pages9
JournalMolecular and Cellular Biology
Volume25
Issue number12
DOIs
StatePublished - Jun 2005

Fingerprint

Dive into the research topics of 'Active Src elevates the expression of β-catenin by enhancement of cap-dependent translation'. Together they form a unique fingerprint.

Cite this